Regulation of Circadian Genes by the MAPK Pathway: Implications for Rapid Antidepressant Action
Accumulating evidence suggests that the circadian rhythm plays a critical role in mood regulation, and circadian disturbances are often found in patients with major depressive disorder (MDD). The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway is involved...
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Published in | Neuroscience bulletin Vol. 36; no. 1; pp. 66 - 76 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Singapore
Springer Singapore
01.01.2020
Springer |
Subjects | |
Online Access | Get full text |
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Summary: | Accumulating evidence suggests that the circadian rhythm plays a critical role in mood regulation, and circadian disturbances are often found in patients with major depressive disorder (MDD). The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway is involved in mediating entrainment of the circadian system. Furthermore, the MAPK/ERK signaling pathway has been shown to be involved in the pathogenesis of MDD and the rapid onset of action of antidepressant therapies, both pharmaceutical and non-pharmaceutical. This review provides an overview of the involvement of the MAPK/ERK pathway in modulating the circadian system in the rapid action of antidepressant therapies. This pathway holds much promise for the development of novel, rapid-onset-of-action therapeutics for MDD. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 1673-7067 1995-8218 |
DOI: | 10.1007/s12264-019-00358-9 |