STIMULATION OF CEPHALOSPORIN PRODUCTION BY METHIONINE PEPTIDES IN A MUTANT BLOCKED IN REVERSE TRANSSULFURATION

The previously reported12) inability of methionine to stimulate cephalosporin C production in a cysteine auxotroph is due to cysteine interference with methionine uptake. In such a case, "illicit transport" of alanylmethionine can be used to demonstrate the efficacy of methionine in such m...

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Bibliographic Details
Published inJournal of antibiotics Vol. 28; no. 11; pp. 889 - 895
Main Authors DREW, STEPHEN W., DEMAIN, ARNOLD L.
Format Journal Article
LanguageEnglish
Published Japan JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.01.1975
Subjects
Acremonium - metabolism
Cephalosporins - biosynthesis
Cysteine - metabolism
Leucine - pharmacology
Methionine - pharmacology
Mutation
Peptides - pharmacology
Sulfur - metabolism
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Summary:The previously reported12) inability of methionine to stimulate cephalosporin C production in a cysteine auxotroph is due to cysteine interference with methionine uptake. In such a case, "illicit transport" of alanylmethionine can be used to demonstrate the efficacy of methionine in such mutants blocked in the path from methionine to cysteine. This result supports the hypothesis that the stimulatory activity of methionine is not due to its ability to donate sulfur to the cephalosporin C molecule.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.28.889