Antituberculosis BCG vaccination: more reasons for varying innate and adaptive immune responses

Bacillus Calmette-Guérin (BCG) vaccination induces variable protection against pulmonary tuberculosis (TB), and a more effective TB vaccine is needed. The potential for BCG to provide protection against heterologous infections, by induction of innate immune memory, is increasingly recognized. These...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of clinical investigation Vol. 130; no. 10; pp. 5121 - 5123
Main Authors Prentice, S, Dockrell, H M
Format Journal Article
LanguageEnglish
Published United States American Society for Clinical Investigation 01.10.2020
Subjects
BCG
BCG Vaccine
Female
Health aspects
Humans
Immune response
Infection
Inflammation
Male
Mycobacterium bovis - immunology
Tuberculosis
Tuberculosis vaccines
Tuberculosis, Pulmonary
Type 2 diabetes
Vaccination
United Kingdom
Online AccessGet full text

Cover

More Information
Summary:Bacillus Calmette-Guérin (BCG) vaccination induces variable protection against pulmonary tuberculosis (TB), and a more effective TB vaccine is needed. The potential for BCG to provide protection against heterologous infections, by induction of innate immune memory, is increasingly recognized. These nonspecific responses may substantially benefit public health, but are also variable. In this issue of the JCI, Koeken and de Bree et al. report that BCG reduces circulating inflammatory markers in males but not in females, while de Bree and Mouritis et al. describe how diurnal rhythms affect the degree of BCG-induced innate memory. These studies further delineate factors that influence the magnitude of responses to BCG and may be crucial to harnessing its potential benefits.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Commentary-3
content type line 23
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI141317