Primary small cell thyroid carcinoma combined with poorly differentiated thyroid carcinoma, evidence for a common origin: A case report

Primary small cell thyroid carcinomas are extremely rare and there is still debate about their classification as a distinct disease entity. The present case report reports a small cell carcinoma (SCC) combined with poorly differentiated thyroid carcinoma (PDTC) in a 34 year old man. The tumor consis...

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Bibliographic Details
Published inOncology letters Vol. 25; no. 6; p. 233
Main Authors Kim, Kyoung Min, Ahn, Ae Ri, Hong, Yong Tae, Chung, Myoung Ja
Format Journal Article
LanguageEnglish
Published Greece Spandidos Publications 01.06.2023
Spandidos Publications UK Ltd
D.A. Spandidos
Subjects
Analysis
Automation
Cancer
Carcinoma
Case reports
Chemotherapy
Cytokeratin
Cytoplasm
Diagnostic reagents industry
Goats
Invoices
Keratin
Lung cancer
Medical colleges
Morphology
Scientific equipment and supplies industry
Thyroid cancer
Thyroid diseases
Thyroid gland
Thyroidectomy
Tomography
United States
United Kingdom
South Korea
poorly differentiated carcinoma
small cell carcinoma
thyroid
next generation sequencing
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Summary:Primary small cell thyroid carcinomas are extremely rare and there is still debate about their classification as a distinct disease entity. The present case report reports a small cell carcinoma (SCC) combined with poorly differentiated thyroid carcinoma (PDTC) in a 34 year old man. The tumor consisted of ~80% PDTC and ~20% SCC. The PDTC component was positive for cytokeratin and thyroid transcription factor-1 (TTF-1), and negative for calcitonin, chromogranin and synaptophysin. The SCC component was positive for synaptophysin and CD56, and negative for calcitonin, chromogranin and TTF-1. Seven months after thyroid surgery, two new lung nodules were detected. Histologically and immunohistochemically, the lung tumors were similar to the SCC component of the thyroid carcinoma. The mutational status of cancer-related genes was assessed using targeted next-generation sequencing in both the thyroid and lung, which identified similar genetic alterations. The histogenesis of SCC was evaluated through NGS analysis of the two cancer components.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2023.13819