The role of cholesterol crystals and ocular crystal emboli in retinal pathology

Cholesterol crystals (CC) can be responsible for a range of clinical syndromes in the retina from asymptomatic plaques to retinal artery occlusion with clinical trials providing evidence for the efficacy in lipid lowering therapies in preventing ocular pathology. Much of the literature has focused o...

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Published inAmerican heart journal plus Vol. 47; p. 100475
Main Authors Medawar, Nicholas G., Dorweiler, Tim F., Abela, George S., Busik, Julia V., Grant, Maria B.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2024
Elsevier
Subjects
Cardiovascular
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Summary:Cholesterol crystals (CC) can be responsible for a range of clinical syndromes in the retina from asymptomatic plaques to retinal artery occlusion with clinical trials providing evidence for the efficacy in lipid lowering therapies in preventing ocular pathology. Much of the literature has focused on CC in retinal circulation as a marker of poor systemic health and have attempted to use them to categorize risk of mortality and stroke. More recently cholesterol accumulation and CC formation have been linked to development of diabetic retinopathy with CC formation in the retina due to aberrant retinal cholesterol homeostasis and not simply systemic dyslipidemia.
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ISSN:2666-6022
2666-6022
DOI:10.1016/j.ahjo.2024.100475