Dry roasting enhances peanut-induced allergic sensitization across mucosal and cutaneous routes in mice

• Published in: Journal of allergy and clinical immunology Vol. 134; no. 6; pp. 1453 - 1456
• Main Authors: Moghaddam, Amin E., MD, Hillson, William R., PhD, Noti, Mario, PhD, Gartlan, Kate H., PhD, Johnson, Steven, PhD, Thomas, Benjamin, PhD, Artis, David, PhD, Sattentau, Quentin J., PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2014; Elsevier; Elsevier Limited
• Subjects: Administration, Cutaneous; Administration, Oral; Age; Allergens - administration & dosage; Allergens - immunology; Allergic diseases; Allergies; Allergy and Immunology; Animals; Antigens, Plant - administration & dosage; Antigens, Plant - immunology; Arachis - chemistry; Arachis - immunology; Biological and medical sciences; Digestive allergic diseases; Food allergies; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gastrointestinal Tract; Glycation End Products, Advanced - chemistry; Glycation End Products, Advanced - immunology; Hot Temperature; Immunoglobulin E - immunology; Immunoglobulin G - immunology; Immunopathology; Medical sciences; Mice, Inbred BALB C; Mucous Membrane; Peanut Hypersensitivity - immunology; Peanuts; Proteins; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Food allergy; Immunopathology; Vertebrata; Mammalia; Immunology; Mouse; Animal; Mucosa; Rodentia; Digestive diseases; Skin; Sensitization
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2014.07.032

[...]phenotypic and cytokine profile analyses of peanut-pulsed BMDCs revealed no classical activation by raw or DR peanut preparations compared with LPS (Fig 2, D and E, and see Fig E7 in this article's Online Repository at www.jacionline.org). [...]by contrast with direct AGE-relevant modification of HEL that showed increased presentation to an HEL-specific T-cell hybridoma, DR PPE-pulsed dendritic cells (DCs) did not enhance the presentation of unmodified HEL, reinforcing the absence of DR PPE-elicited DC costimulation (Fig 2, F, and see Fig E8 in this article's Online Repository at www.jacionline.org).