Serum procalcitonin as a biomarker differentiating delayed-type drug hypersensitivity from systemic bacterial infection

• Published in: Journal of allergy and clinical immunology Vol. 132; no. 4; pp. 981 - 983
• Main Authors: Yoon, Sun-Young, MD, Baek, Seung Hee, PhD, Kim, Sujeong, MD, Lee, Yoon Su, MD, Lee, Taehoon, MD, Bae, Yun-Jeong, MD, Kwon, Hyouk-Soo, MD, PhD, Huh, Jin Won, MD, PhD, Hong, Sang-Bum, MD, PhD, Cho, You Sook, MD, PhD, Chun, Sail, MD, PhD, Lim, Chae-Man, MD, PhD, Koh, Younsuck, MD, PhD, Moon, Hee-Bom, MD, PhD, Kim, Tae-Bum, MD, PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.10.2013; Elsevier; Elsevier Limited
• Subjects: Adult; Aged; Allergic diseases; Allergy and Immunology; Antibiotics; Bacterial infections; Bacterial Infections - blood; Bacterial Infections - diagnosis; Biological and medical sciences; Biomarkers; C-Reactive Protein - analysis; Calcitonin - blood; Calcitonin Gene-Related Peptide; Diagnosis, Differential; Disease; Drug Hypersensitivity - blood; Drug Hypersensitivity - diagnosis; Drug Hypersensitivity - physiopathology; Drugs; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Hospitals; Humans; Hypersensitivity, Delayed - blood; Hypersensitivity, Delayed - diagnosis; Immunopathology; Infections; Intensive care; Laboratories; Medical sciences; Middle Aged; Multivariate analysis; Protein Precursors - blood; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Sepsis; Skin allergic diseases. Stinging insect allergies; Viral infections; Infection; Drug; Allergy; Immunopathology; Immunology; Procalcitonin; Bacteriosis; Biological marker; Serum; Delayed hypersensitivity
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2013.04.038

[...]the diagnosis of drug hypersensitivity is clinical and is a diagnosis of exclusion, because laboratory measurements are rarely helpful to diagnose it. [...]the levels of serum procalcitonin may be a better biomarker than serum CRP levels for distinguishing delayed-type drug hypersensitivity from systemic bacterial infection.