Genetic characterization of hantaviruses transmitted by the Korean field mouse (Apodemus peninsulae), Far East Russia

• Published in: Emerging infectious diseases Vol. 8; no. 8; pp. 768 - 776
• Main Authors: Lokugamage, Kumari, Kariwa, Hiroaki, Hayasaka, Daisuke, Cui, Bai Zhong, Iwasaki, Takuya, Lokugamage, Nandadeva, Ivanov, Leonid I, Volkov, Vladimir I, Demenev, Vladimir A, Slonova, Raisa, Kompanets, Galina, Kushnaryova, Tatyana, Kurata, Takeshi, Maeda, Kenji, Araki, Koichi, Mizutani, Tetsuya, Yoshimatsu, Kumiko, Arikawa, Jiro, Takashima, Ikuo
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.08.2002; Centers for Disease Control and Prevention
• Subjects: Analysis; Animals; Antibodies, Viral - blood; Apodemus peninsulae; Base Sequence; Carrier State - transmission; Carrier State - veterinary; Carrier State - virology; Cladistic analysis; DNA, Viral - genetics; Far East Russia; Genetic Variation; Hantavirus; Hantavirus infections; Hantavirus Infections - transmission; Hantavirus Infections - veterinary; Hantavirus Infections - virology; hemorrhagic fever with renal syndrome; HFRS; Humans; Identification and classification; Mice - virology; Molecular Sequence Data; Nucleotide sequence; Orthohantavirus - classification; Orthohantavirus - genetics; Orthohantavirus - isolation & purification; Phylogeny; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral - genetics; Russia; Sequence Homology, Nucleic Acid; Voles; Russia; Japan
• ISSN: 1080-6040; 1080-6059
• DOI: 10.3201/eid0808.010494

In an epizootiologic survey of 122 rodents captured in Vladivostok, Russia, antibodies positive for hantavirus were found in Apodemus peninsulae (4/70), A. agrarius (1/39), and Clethrionomys rufocanus (1/8). The hantavirus sequences identified in two seropositive A. peninsulae and two patients with hemorrhagic fever with renal syndrome (HFRS) from the Primorye region of Far East Russia were designated as Solovey and Primorye, respectively. The nucleotide sequences of the Solovey, Primorye, and Amur (obtained through GenBank) sequences were closely related (>92% identity). Solovey and Primorye sequences shared 84% nucleotide identity with the prototype Hantaan 76-118. Phylogenetic analysis also indicated a close relationship between Solovey, Primorye, Amur, and other viruses identified in Russia, China, and Korea. Our findings suggest that the Korean field mouse (A. peninsulae) is the reservoir for a hantavirus that causes HFRS over a vast area of east Asia, including Far East Russia.