The scales and tales of myelination: using zebrafish and mouse to study myelinating glia

• Published in: Brain research Vol. 1641; no. Pt A; pp. 79 - 91
• Main Authors: Ackerman, Sarah D, Monk, Kelly R
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.06.2016
• Subjects: Animals; Biological Evolution; Humans; Mice - growth & development; Mice - physiology; Mouse; Myelin; Myelin Sheath - physiology; Nerve Regeneration - physiology; Neurology; Oligodendrocyte; Schwann cell; Zebrafish; Zebrafish - growth & development; Zebrafish - physiology; aGPCR; NTF; OPC; E; TALENs; insertion and deletion; BL; pLLn; GPS; cAMP; transcription activator-like effector nucleases; oligodendrocyte precursor cell; SC; posterior lateral line nerve; clustered regularly interspaced short palindromic repeats-CRISPR associated; Schwann cell; CRISPR-Cas; embryonic day; days post-fertilization; dpf; protein kinase A; GPCR autoproteolysis-inducing; OL; GAIN; hpf; 3′,5′-cyclic monophosphate; mpf; Myelin; C-terminal fragment; oligodendrocyte; PKA; adhesion G protein-coupled receptor; hours post-fertilization; Zebrafish; N-terminal fragment; GPCR proteolytic site; CTF; Mouse; basal lamina; months post-fertilization; indel; Oligodendrocyte

Abstract Myelin, the lipid-rich sheath that insulates axons to facilitate rapid conduction of action potentials, is an evolutionary innovation of the jawed-vertebrate lineage. Research efforts aimed at understanding the molecular mechanisms governing myelination have primarily focused on rodent mode...