The role of calcium in the regulation of apoptosis

The recognition that apoptosis is regulated by an evolutionarily conserved set of polypeptides from the nematode Caenorhabditis elegant to humans suggests that a conserved set of biochemical mechanism(s) may also be involved in the response. Work from a number of independent laboratories suggests th...

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Bibliographic Details
Published inJournal of leukocyte biology Vol. 59; no. 6; pp. 775 - 783
Main Authors McConkey, David J., Orrenius, Sten
Format Journal Article
LanguageEnglish
Published United States Society for Leukocyte Biology 01.06.1996
Subjects
Animals
Apoptosis
BCL‐2
Calcium - physiology
Ceramides - biosynthesis
endonuclease
Endonucleases - physiology
Endopeptidases - physiology
Homeostasis
Humans
Medicin och hälsovetenskap
Oxidative Stress
Signal Transduction
Transglutaminases - physiology
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Summary:The recognition that apoptosis is regulated by an evolutionarily conserved set of polypeptides from the nematode Caenorhabditis elegant to humans suggests that a conserved set of biochemical mechanism(s) may also be involved in the response. Work from a number of independent laboratories suggests that alterations in cytosolic Ca2+ homeostasis represent one such candidate mechanism, and molecular targets for Ca2+ are now being identified. This review will summarize what is known about the role of Ca2+ in the regulation of apoptosis and discuss how Ca2+ might interact with some of the other biochemical signals implicated in cell death.
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ISSN:0741-5400
1938-3673
DOI:10.1002/jlb.59.6.775