Differential engagement of anterior cingulate cortex subdivisions for cognitive and emotional function

Functional differentiation of dorsal (dACC) and rostral (rACC) anterior cingulate cortex for cognitive and emotional function has received considerable indirect support. Using fMRI, parallel tasks, and within‐subject analysis, the present study directly tested the proposed specialization of ACC subd...

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Published inPsychophysiology Vol. 44; no. 3; pp. 343 - 351
Main Authors Mohanty, Aprajita, Engels, Anna S., Herrington, John D., Heller, Wendy, Ringo Ho, Moon-Ho, Banich, Marie T., Webb, Andrew G., Warren, Stacie L., Miller, Gregory A.
Format Journal Article
LanguageEnglish
Published Malden, USA Blackwell Publishing Inc 01.05.2007
Blackwell Publishing Ltd
Subjects
Adolescent
Adult
Anterior cingulate
Attention - physiology
Brain Mapping
Cognition
Cognition & reasoning
Cognition - physiology
Color Perception - physiology
Conflict (Psychology)
Discrimination Learning - physiology
Dominance, Cerebral - physiology
Emotion
Emotions
Emotions - physiology
Female
fMRI
Functional connectivity
Gyrus Cinguli - physiology
Humans
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Male
Neuropsychological Tests
Physiological psychology
Problem Solving - physiology
Reading
Semantics
Stroop
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Summary:Functional differentiation of dorsal (dACC) and rostral (rACC) anterior cingulate cortex for cognitive and emotional function has received considerable indirect support. Using fMRI, parallel tasks, and within‐subject analysis, the present study directly tested the proposed specialization of ACC subdivisions. A Task × Region interaction confirmed more dACC activation during color‐word distractors and more rACC activation during emotion‐word distractors. Activity in ACC subdivisions differentially predicted behavioral performance. Connectivity with prefrontal and limbic regions also supported distinct dACC and rACC roles. Findings provide direct evidence for differential engagement of ACC subdivisions in cognitive and emotional processing and for differential functional connectivity in the implementation of cognitive control and emotion regulation. Results point to an anatomical and functional continuum rather than segregated operations.
Bibliography:ark:/67375/WNG-WLMCS5ZS-1
ArticleID:PSYP515
istex:E851096AD1E329D32F132325545A773BF259EE4B
The authors thank Emily Cahill, Nancy Dodge, Rebecca Levin, Sarah Sass, Brad Sutton, Holly Tracy, and Tracey Wszalek for their contributions to this project.
This research was supported by the National Institute of Drug Abuse (R21 DA14111), the National Institute of Mental Health (R01 MH61358, T32 MH14257, T32 MH19554), and the University of Illinois Beckman Institute and Intercampus Research Initiative in Biotechnology. Anna S. Engels was a predoctoral trainee in the Cognitive Psychophysiology training program of the Department of Psychology, University of Illinois at Urbana–Champaign, under NIMH Grant T32 MH19554. John D. Herrington was a predoctoral trainee in the Quantitative Methods training program of the Department of Psychology, University of Illinois at Urbana–Champaign, under NIMH Grant T32 MH14257.
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SourceType-Scholarly Journals-1
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ISSN:0048-5772
1540-5958
1469-8986
DOI:10.1111/j.1469-8986.2007.00515.x