A comprehensive pathway map of epidermal growth factor receptor signaling

The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells. Reflecting this importance, it is one of the best‐investigated signaling systems, both experimentally and computa...

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Published inMolecular systems biology Vol. 1; no. 1; pp. 2005.0010 - n/a
Main Authors Kitano, Hiroaki, Oda, Kanae, Matsuoka, Yukiko, Funahashi, Akira
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 2005
EMBO Press
Subjects
Acids
Animals
Apoptosis
Biology
Bone cancer
Cell cycle
Cell differentiation
Cell division
Cell proliferation
Computer applications
Computer simulation
Endocytosis
Endoplasmic reticulum
Enzyme Activation
Epidermal growth factor
Epidermal growth factor receptors
ErbB Receptors - physiology
Feedback loops
Feedback, Physiological
Growth factors
Humans
Kinases
Leukemia
Lymphoma
Mammalian cells
Mathematical models
Models, Biological
Molecular interactions
Multigene Family
Phosphatase
Phosphorylation
Programming Languages
Protein Interaction Mapping
Proteins
Receptors, G-Protein-Coupled - physiology
Researchers
Review
Science
Signal Transduction
Signalling systems
Software
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Summary:The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells. Reflecting this importance, it is one of the best‐investigated signaling systems, both experimentally and computationally, and several computational models have been developed for dynamic analysis. A map of molecular interactions of the EGFR signaling system is a valuable resource for research in this area. In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways. The map reveals that the overall architecture of the pathway is a bow‐tie (or hourglass) structure with several feedback loops. The map is created using CellDesigner software that enables us to graphically represent interactions using a well‐defined and consistent graphical notation, and to store it in Systems Biology Markup Language (SBML).
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ISSN:1744-4292
1744-4292
DOI:10.1038/msb4100014