Association between serum uric acid concentration and radiographic axial spondylarthritis: a cross-sectional study of 202 patients

• Published in: Chinese medical journal Vol. 136; no. 9; pp. 1114 - 1116
• Main Authors: Lai, Yupeng, Zhang, Yanpeng, Lei, Zhihao, Huang, Yihong, Ni, Tongxin, He, Pin, Li, Xiaoling, Xu, Chiduo, Xia, Jun, Wang, Meiying
• Format: Journal Article
• Language: English
• Published: China Lippincott Williams & Wilkins 05.05.2023; Lippincott Williams & Wilkins Ovid Technologies; Department of Rheumatology and Immunology, Shenzhen Second People’s Hospital, Shenzhen, Guangdong 510000, China%Department of Laboratory, Shenzhen Second People’s Hospital, Shenzhen, Guangdong 510000, China%Department of Neurology, Shenzhen Second People’s Hospital, Shenzhen, Guangdong 510000, China%Department of Cardiology, Shenzhen University General Hospital, Shenzhen, Guangdong 510000, China%Department of Radiology, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, Guangdong 510000, China%Community Health Service Management Center, The Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong 510000, China%Department of Radiology, Shenzhen Second People’s Hospital, Shenzhen, Guangdong 510000, China; Wolters Kluwer
• Subjects: Arthritis; C-Reactive Protein; Cartilage; Correspondence; Creatinine; Cross-Sectional Studies; Disease; Gender; Humans; Inflammatory bowel disease; Mineralization; Missing data; Patients; Psoriasis; Regression analysis; Rheumatism; Sacroiliitis; Spondylarthritis - diagnostic imaging; Spondylitis, Ankylosing; Tumor necrosis factor-TNF; Uric Acid
• ISSN: 0366-6999; 2542-5641; 2542-5641
• DOI: 10.1097/CM9.0000000000002148

Furthermore, it has been reported that gout could mimic SpA. [...]our study explored whether the development of radiographic axial SpA is related to high SUA concentration. The unit of measurement for uric acid was μmol/L, which was relatively small for observing changes. [...]we transformed the unit of measurement for uric acid from μmol/L into 10 μmol/L, after collecting the raw data on uric acid levels. No significant difference was found between the radiographic group and the non-radiographic group with respect to age, gout, peripheral involvement, enthesitis, dactylitis, uveitis, psoriasis, inflammatory bowel disease (IBD), erythrocyte sedimentation rate (ESR), CRP, creatinine, BASFI, and NSAID usage. According to the previous report about MSU deposition at sacroiliac joints and our discovery about the relationship between SUA and radiographic axial SpA, we found that SUA was another possible factor for sacroiliitis progression.