Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery

• Published in: Nature communications Vol. 15; no. 1; pp. 4366 - 14
• Main Authors: Zelepukin, Ivan V., Shevchenko, Konstantin G., Deyev, Sergey M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.05.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/57/2282; 639/301/54/990; 639/301/923/3931; 639/925/352/152; Animals; Blood circulation; Drug carriers; Drug delivery; Drug delivery systems; Drug Delivery Systems - methods; Effectiveness; Humanities and Social Sciences; Humans; Immune system; Meta-analysis; Methods; Mononuclear phagocyte system; Mononuclear Phagocyte System - metabolism; multidisciplinary; Nanoparticle Drug Delivery System - chemistry; Nanoparticles; Nanoparticles - chemistry; Neoplasms - drug therapy; Neoplasms - immunology; Perspective; Polyethylene glycol; Regulatory approval; Science; Science (multidisciplinary); Side effects; Toxicity; Translation; Tumors
• ISSN: 2041-1723; 1460-7018; 1360-3108; 2041-1723; 1460-7018
• DOI: 10.1038/s41467-024-48838-5

Rapid uptake of nanoparticles by mononuclear phagocyte system (MPS) significantly hampers their therapeutic efficacy. Temporal MPS blockade is one of the few ways to overcome this barrier – the approach rediscovered many times under different names but never extensively used in clinic. Using meta-analysis of the published data we prove the efficacy of this technique for enhancing particle circulation in blood and their delivery to tumours, describe a century of its evolution and potential combined mechanism behind it. Finally, we discuss future directions of the research focusing on the features essential for successful clinical translation of the method. Temporal blockade of the mononuclear phagocyte system is an approach to enhance the therapeutic efficiency of nanocarrier drug-delivery systems but the broad applicability is hindered by the complexity of optimisation and management of potential side effects. Here, the authors review the development of this technique and show its efficiency using meta-analysis of the published data and discuss essential features for its successful translation to clinic.