Glycosphingolipid GM2 Induces Invasiveness in Irradiation-tolerant Lung Cancer Cells

Glycans, including glycosphingolipids, are broadly expressed in plasma membranes and play important roles in cell-cell interactions. Recently, it has been revealed that glycans participate in the regulation of malignant phenotypes of cancer cells, e.g. growth and invasion. However, their roles in ir...

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Published inCell Structure and Function Vol. 43; no. 2; pp. 177 - 185
Main Authors Ishihara, Seiichiro, Aoki, Kei, Mizutani, Takeomi, Amano, Maho, Nishimura, Shin-Ichiro, Haga, Hisashi
Format Journal Article
LanguageEnglish
Published Japan Japan Society for Cell Biology 01.01.2018
Japan Science and Technology Agency
Subjects
A549 Cells
Cadherins - metabolism
Cell interactions
Cell Movement - radiation effects
Cell Survival - radiation effects
G(M2) Activator Protein - antagonists & inhibitors
G(M2) Activator Protein - genetics
G(M2) Activator Protein - metabolism
Galactosyltransferases - metabolism
Glycosphingolipids
Glycosphingolipids - analysis
Glycosphingolipids - metabolism
GM2
Humans
invasion
Invasiveness
Kaplan-Meier Estimate
Lung cancer
lung cancer cells
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Microscopy, Fluorescence
Phenotypes
Plasma membranes
Polysaccharides
Prognosis
Proportional Hazards Models
Radiation therapy
Radiation, Ionizing
radiotherapy
RNA Interference
RNA, Small Interfering - metabolism
Tandem Mass Spectrometry
Therapeutic applications
Switzerland
Japan
Germany
radiotherapy
invasion
lung cancer cells
GM2
glycosphingolipids
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Summary:Glycans, including glycosphingolipids, are broadly expressed in plasma membranes and play important roles in cell-cell interactions. Recently, it has been revealed that glycans participate in the regulation of malignant phenotypes of cancer cells, e.g. growth and invasion. However, their roles in irradiation-tolerant cancer cells have not yet been elucidated. In this study, we show that specific glycosphingolipids are highly expressed in invasive, irradiation-tolerant lung cancer cells. Particularly, the glycosphingolipid GM2 contributes to the development of an invasive phenotype in these lung cancer cells. Our results suggest that glycosphingolipids, including GM2, are implicated in the regulation of invasiveness in irradiation-tolerant lung cancer cells and may therefore serve as potential therapeutic targets for lung cancers following radiotherapy.Key words: glycosphingolipids, GM2, invasion, lung cancer cells, radiotherapy
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0386-7196
1347-3700
DOI:10.1247/csf.18026