Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats

• Published in: British journal of nutrition Vol. 96; no. 4; pp. 660 - 666
• Main Authors: Al-Amin, Zainab M., Thomson, Martha, Al-Qattan, Khaled K., Peltonen-Shalaby, Riitta, Ali, Muslim
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.10.2006
• Subjects: animal disease models; Animals; Anti-diabetic properties; Antidiabetics; Biological and medical sciences; Blood; blood glucose; Blood Glucose - metabolism; blood lipids; chemical composition; cholesteremic effect; Cholesterol; Cholesterol - blood; Diabetes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - drug therapy; drinking water; drug therapy; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Ginger; ginger root; Glucose; glycemic effect; hyperglycemia; Hypoglycaemic properties; Hypoglycemic Agents; Hypoglycemic Agents - therapeutic use; Hypolipidaemic properties; Hypolipidemic Agents; Hypolipidemic Agents - therapeutic use; intraperitoneal injection; lipemic effect; Male; metabolism; methods; Nutrition research; Phytotherapy; Phytotherapy - methods; Plant Extracts; Plant Extracts - therapeutic use; Proteinuria; Proteinuria - drug therapy; Rats; Rats, Sprague-Dawley; specialty crops; therapeutic use; triacylglycerols; Triglycerides; Triglycerides - blood; urine; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Zingiber officinale; Kuwait; Anti-diabetic properties; Hypolipidaemic properties; Diabetes; Ginger; Hypoglycaemic properties; Proteinuria; Endocrinopathy; Vertebrata; Urinary system disease; Mammalia; Rat; Animal; Diabetes mellitus; Rodentia; Streptozotocin; Anti-diabetic properties: Diabetes: Ginger: Hypoglycaemic properties: Hypolipidaemic properties: Proteinuria
• ISSN: 0007-1145; 1475-2662
• DOI: 10.1079/BJN20061849

In the present study, the hypoglycaemic potentials of ginger (Zingiber officinale) were studied in rats. An aqueous extract of raw ginger was administered daily (500 mg/kg, intraperitoneally) for a period of 7 weeks to streptozotocin (STZ)-induced diabetic rats. Fasting blood serum was analysed for blood glucose, cholesterol and triacylglycerol levels. The STZ-injected rats exhibited hyperglycaemia accompanied with weight loss, indicating their diabetic condition. At a dose of 500 mg/kg, raw ginger was significantly effective in lowering serum glucose, cholesterol and triacylglycerol levels in the ginger-treated diabetic rats compared with the control diabetic rats. The ginger treatment also resulted in a significant reduction in urine protein levels. In addition, the ginger-treated diabetic rats sustained their initial weights during the treatment period. Moreover, ginger decreased both water intake and urine output in the STZ-induced diabetic rats. The present results indicate that raw ginger possesses hypoglycaemic, hypocholesterolaemic and hypolipidaemic potential. Additionally, raw ginger is effective in reversing the diabetic proteinuria observed in the diabetic rats. Thus, ginger may be of great value in managing the effects of diabetic complications in human subjects.