Mechanisms of HIV-associated lymphocyte apoptosis: 2010

The inevitable decline of CD4T cells in untreated infection with the Human immunodeficiency virus (HIV) is due in large part to apoptosis, one type of programmed cell death. There is accumulating evidence that the accelerated apoptosis of CD4T cells in HIV infection is multifactorial, with direct vi...

Full description

Saved in:
Bibliographic Details
Published inCell death & disease Vol. 1; no. 11; p. e99
Main Authors Cummins, N W, Badley, A D
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.11.2010
Springer Nature B.V
Nature Publishing Group
Subjects
631/250/1619/554/1898
631/80/82/23
692/420/2780
692/699/249/1570/1901
Antibodies
Antiviral Agents - therapeutic use
Apoptosis
Biochemistry
Biomedical and Life Sciences
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - metabolism
CD4-Positive T-Lymphocytes - virology
Cell Biology
Cell Culture
Fas Ligand Protein - metabolism
fas Receptor - metabolism
HIV - enzymology
HIV - metabolism
HIV - physiology
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - virology
Human immunodeficiency virus
Humans
Immunology
Life Sciences
Review
TNF-Related Apoptosis-Inducing Ligand - metabolism
Tumor Necrosis Factor-alpha - metabolism
Viral Proteins - metabolism
apoptosis
immunopathogenesis
HIV
T-cell
Online AccessGet full text

Cover

More Information
Summary:The inevitable decline of CD4T cells in untreated infection with the Human immunodeficiency virus (HIV) is due in large part to apoptosis, one type of programmed cell death. There is accumulating evidence that the accelerated apoptosis of CD4T cells in HIV infection is multifactorial, with direct viral cytotoxicity, signaling events triggered by viral proteins and aberrant immune activation adding to normal immune defense mechanisms to contribute to this phenomenon. Current antiviral treatment strategies generally lead to reduced apoptosis, but this approach may come at the cost of preserving latent viral reservoirs. It is the purpose of this review to provide an update on the current understanding of the role and mechanisms of accelerated apoptosis of T cells in the immunopathogenesis of HIV infection, and to highlight potential ways in which this seemingly deleterious process could be harnessed to not just control, but treat HIV infection.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-3
ObjectType-Review-1
ISSN:2041-4889
2041-4889
DOI:10.1038/cddis.2010.77