Persistent akathisia masquerading as agitated depression after use of ziprasidone in the treatment of bipolar depression
There has been increasing recognition that the second-generation antipsychotic drugs can produce extrapyramidal side effects. This case reports the development of severe akathisia in a patient being treated with ziprasidone for bipolar depression. The case illustrates that this symptom can be easily...
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| Published in | Neuropsychiatric disease and treatment Vol. 9; no. default; pp. 463 - 465 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
New Zealand
Dove Medical Press Limited
01.01.2013
Taylor & Francis Ltd Dove Press Dove Medical Press |
| Subjects | |
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| Abstract | There has been increasing recognition that the second-generation antipsychotic drugs can produce extrapyramidal side effects. This case reports the development of severe akathisia in a patient being treated with ziprasidone for bipolar depression. The case illustrates that this symptom can be easily mistaken for worsening agitated depression. Akathisia may produce considerable distress and elevate suicide risk. Such symptoms may persist for weeks and be refractory to discontinuation of the offending agent or to pharmacological interventions commonly used to mitigate this reaction. |
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| AbstractList | There has been increasing recognition that the second-generation antipsychotic drugs can produce extrapyramidal side effects. This case reports the development of severe akathisia in a patient being treated with ziprasidone for bipolar depression. The case illustrates that this symptom can be easily mistaken for worsening agitated depression. Akathisia may produce considerable distress and elevate suicide risk. Such symptoms may persist for weeks and be refractory to discontinuation of the offending agent or to pharmacological interventions commonly used to mitigate this reaction. Keywords: extrapyramidal, second-generation, affective, antipsychotic, suicide, mood disorder There has been increasing recognition that the second-generation antipsychotic drugs can produce extrapyramidal side effects. This case reports the development of severe akathisia in a patient being treated with ziprasidone for bipolar depression. The case illustrates that this symptom can be easily mistaken for worsening agitated depression. Akathisia may produce considerable distress and elevate suicide risk. Such symptoms may persist for weeks and be refractory to discontinuation of the offending agent or to pharmacological interventions commonly used to mitigate this reaction. Thomas M Penders,1 Salina Agarwal,2 Rachel Rohaidy11Department of Psychiatric Medicine, Brody School of Medicine, East Carolina University, Greenville, NC, USA; 2Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USAAbstract: There has been increasing recognition that the second-generation antipsychotic drugs can produce extrapyramidal side effects. This case reports the development of severe akathisia in a patient being treated with ziprasidone for bipolar depression. The case illustrates that this symptom can be easily mistaken for worsening agitated depression. Akathisia may produce considerable distress and elevate suicide risk. Such symptoms may persist for weeks and be refractory to discontinuation of the offending agent or to pharmacological interventions commonly used to mitigate this reaction.Keywords: extrapyramidal, second-generation, affective, antipsychotic, suicide, mood disorder |
| Audience | Academic |
| Author | Penders, Thomas M Agarwal, Salina Rohaidy, Rachel |
| AuthorAffiliation | 2 Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA 1 Department of Psychiatric Medicine, Brody School of Medicine, East Carolina University, Greenville, NC, USA |
| AuthorAffiliation_xml | – name: 1 Department of Psychiatric Medicine, Brody School of Medicine, East Carolina University, Greenville, NC, USA – name: 2 Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23589691$$D View this record in MEDLINE/PubMed |
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| Copyright | COPYRIGHT 2013 Dove Medical Press Limited 2013. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2013 Penders et al, publisher and licensee Dove Medical Press Ltd. 2013 |
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| Keywords | extrapyramidal antipsychotic mood disorder second-generation affective suicide |
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| Snippet | There has been increasing recognition that the second-generation antipsychotic drugs can produce extrapyramidal side effects. This case reports the development... Thomas M Penders,1 Salina Agarwal,2 Rachel Rohaidy11Department of Psychiatric Medicine, Brody School of Medicine, East Carolina University, Greenville, NC,... |
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| SubjectTerms | affective Antidepressants antipsychotic Bipolar disorder Care and treatment Case Report Case studies Complications and side effects Diagnosis extrapyramidal Mental depression mood disorder Restless legs syndrome Risk factors second-generation suicide Ziprasidone |
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| Title | Persistent akathisia masquerading as agitated depression after use of ziprasidone in the treatment of bipolar depression |
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