Persistent akathisia masquerading as agitated depression after use of ziprasidone in the treatment of bipolar depression

There has been increasing recognition that the second-generation antipsychotic drugs can produce extrapyramidal side effects. This case reports the development of severe akathisia in a patient being treated with ziprasidone for bipolar depression. The case illustrates that this symptom can be easily...

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Bibliographic Details
Published inNeuropsychiatric disease and treatment Vol. 9; no. default; pp. 463 - 465
Main Authors Penders, Thomas M, Agarwal, Salina, Rohaidy, Rachel
Format Journal Article
LanguageEnglish
Published New Zealand Dove Medical Press Limited 01.01.2013
Taylor & Francis Ltd
Dove Press
Dove Medical Press
Subjects
affective
Antidepressants
antipsychotic
Bipolar disorder
Care and treatment
Case Report
Case studies
Complications and side effects
Diagnosis
extrapyramidal
Mental depression
mood disorder
Restless legs syndrome
Risk factors
second-generation
suicide
Ziprasidone
United States
extrapyramidal
antipsychotic
mood disorder
second-generation
affective
suicide
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Summary:There has been increasing recognition that the second-generation antipsychotic drugs can produce extrapyramidal side effects. This case reports the development of severe akathisia in a patient being treated with ziprasidone for bipolar depression. The case illustrates that this symptom can be easily mistaken for worsening agitated depression. Akathisia may produce considerable distress and elevate suicide risk. Such symptoms may persist for weeks and be refractory to discontinuation of the offending agent or to pharmacological interventions commonly used to mitigate this reaction.
ISSN:1176-6328
1176-6328
1178-2021
DOI:10.2147/NDT.S43113