Micropower CMOS Integrated Low-Noise Amplification, Filtering, and Digitization of Multimodal Neuropotentials

• Published in: IEEE transactions on biomedical circuits and systems Vol. 3; no. 1; pp. 1 - 10
• Main Authors: Mollazadeh, M., Murari, K., Cauwenberghs, G., Thakor, N.
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.02.2009; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Analog VLSI; Analog-digital conversion; Bandwidth; biopotential amplifier; CMOS digital integrated circuits; CMOS integrated circuits; CMOS process; digital telemetry; electrocorticogram; electroencephalogram; Electroencephalography; Filtering; local field potentials; micropower instrumentation; neural interface; Noise; Signal processing; Signal resolution; Tunable circuits and devices
• ISSN: 1932-4545; 1940-9990
• DOI: 10.1109/TBCAS.2008.2005297

Electrical activity in the brain spans a wide range of spatial and temporal scales, requiring simultaneous recording of multiple modalities of neurophysiological signals in order to capture various aspects of brain state dynamics. Here, we present a 16-channel neural interface integrated circuit fabricated in a 0.5 mum 3M2P CMOS process for selective digital acquisition of biopotentials across the spectrum of neural signal modalities in the brain, ranging from single spike action potentials to local field potentials (LFP), electrocorticograms (ECoG), and electroencephalograms (EEG). Each channel is composed of a tunable bandwidth, fixed gain front-end amplifier and a programmable gain/resolution continuous-time incremental DeltaSigma analog-to-digital converter (ADC). A two-stage topology for the front-end voltage amplifier with capacitive feedback offers independent tuning of the amplifier bandpass frequency corners, and attains a noise efficiency factor (NEF) of 2.9 at 8.2 kHz bandwidth for spike recording, and a NEF of 3.2 at 140 Hz bandwidth for EEG recording. The amplifier has a measured midband gain of 39.6 dB, frequency response from 0.2 Hz to 8.2 kHz, and an input-referred noise of 1.94 mu V rms while drawing 12.2 muA of current from a 3.3 V supply. The lower and higher cutoff frequencies of the bandpass filter are adjustable from 0.2 to 94 Hz and 140 Hz to 8.2 kHz, respectively. At 10-bit resolution, the ADC has an SNDR of 56 dB while consuming 76 muW power. Time-modulation feedback in the ADC offers programmable digital gain (1-4096) for auto-ranging, further improving the dynamic range and linearity of the ADC. Experimental recordings with the system show spike signals in rat somatosensory cortex as well as alpha EEG activity in a human subject.