Efficacy of two calcium phosphate pastes on the remineralization of artificial caries： a randomized controlled double-blind in situ study

• Published in: International journal of oral science Vol. 5; no. 4; pp. 224 - 228
• Main Authors: Vanichvatana, Somkamol, Auychai, Prim
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2013; Springer Nature B.V; Department of Pediatric Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand; Nature Publishing Group
• Subjects: 692/308/2779/109; 692/700; Calcium Phosphates - therapeutic use; Cariostatic Agents - therapeutic use; Caseins - therapeutic use; Cross-Over Studies; Dental Caries - prevention & control; Dental Enamel - drug effects; Dentifrices - therapeutic use; Dentistry; Double-Blind Method; Female; Fluorides - therapeutic use; Humans; Image Processing, Computer-Assisted - methods; Male; Medicine; Microscopy, Polarization; Oral and Maxillofacial Surgery; Original; original-article; Orthopedics; Surgical Orthopedics; Tooth Remineralization - methods; Toothbrushing - methods; Toothpastes - therapeutic use; Treatment Outcome; Young Adult; 人工; 再矿化; 原位; 含氟牙膏; 疗效; 磷酸二钙; 糊剂; 随机; remineralization; fluoride; casein phosphopeptide-amorphous calcium phosphate; functionalized tricalcium phosphate; Clinpro
• ISSN: 1674-2818; 2049-3169
• DOI: 10.1038/ijos.2013.67

To test the efficacy of two calcium phosphate pastes compared to that of fluoride toothpaste on remineralizing artificial caries in situ, this study had a double-blind crossover in situ design, involving three experimental phases of 14 days each, with an 8-day washout period between phases. Nine healthy subjects participated in the study. The subjects wore removable palatal appliances mounted with six human enamel slabs with artificial caries lesions, and in each of the experimental phases, used one of the following methods two times/day： group A, brushing with 1.0 g of Colgate Regular Flavor, followed by applying 0.25 g of Tooth Mousse Plus; group B, brushing with 0.25 g of Clinpro Tooth Crbme; and group C, brushing with 1.0 g of Colgate Regular Flavor. After 14 days, the enamel slabs （54 slabs/ group） were embedded in resin, sectioned and examined with a polarized-light microscope, and the lesion areas were quantified using Image-Pro Plus. All experimental groups showed a significant reduction in lesion area compared to the initial lesion area （paired t-test, P〈O.O01）. The mean reduction in lesion area of Groups A, B and C were （0.029__.0.010）, （0.030_＋0.009） and （0.027_＋0.009） mm2, respectively. There were no statistical differences between groups （KruskaI-Wallis test, P〉0.05）. All three groups remineralized the enamel slab lesions, indicating model sensitivity to fluoride. Given the differences in usage amounts and treated regimens, Clinpro Tooth Crbme provided similar benefits to the fluoride toothpaste; however, no additional benefit of Tooth Mousse Plus was observed when used in conjunction with the fluoride toothpaste.