Efficacy of voriconazole in a murine model of invasive paecilomycosis

• Published in: International journal of antimicrobial agents Vol. 35; no. 4; pp. 362 - 365
• Main Authors: Rodríguez, M. Mar, Pastor, F. Javier, Serena, Carolina, Guarro, Josep
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.04.2010; Elsevier
• Subjects: Amphotericin B; Amphotericin B - therapeutic use; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal Agents - therapeutic use; Biological and medical sciences; Citrus paradisi; Colony Count, Microbial; Diet - methods; Immunocompromised Host; Infectious Disease; Kidney - microbiology; Liver - microbiology; Male; Medical sciences; Mice; Mycoses - drug therapy; Mycoses - microbiology; Paecilomyces - drug effects; Paecilomyces lilacinus; Pharmacology. Drug treatments; Pyrimidines - therapeutic use; Spleen - microbiology; Survival Analysis; Treatment Outcome; Triazoles - therapeutic use; Voriconazole; Paecilomyces lilacinus; Mice; Amphotericin B; Voriconazole; Animal model; Swamp cancer; Mycosis; Azole derivatives; Paecilomycosis; Fungi; Antiprotozoal agent; Antifungal agent; Paecilomyces; Fungi Imperfecti; Treatment efficiency; Rodentia; Infection; Vertebrata; Antibiotic; Mammalia; Mouse; Polyenic compound; Animal; Triazole derivatives; Parasiticide
• ISSN: 0924-8579; 1872-7913
• DOI: 10.1016/j.ijantimicag.2009.11.018

Abstract We studied the efficacy of voriconazole (VRC) and amphotericin B (AMB) in an immunosuppressed murine model of disseminated infection by two strains of Paecilomyces lilacinus . Mice were treated with VRC 60 mg/kg/day orally or AMB 3 mg/kg/day intraperitoneally, beginning 1 day after infection and continuing for 9 days. To avoid rapid clearance of VRC, animals receiving VRC and the control group were given grapefruit juice instead of water. VRC significantly prolonged survival with respect to the group treated with AMB and the control group for both strains ( P = 0.005 and P < 0.0001, respectively, for strain FMR 5522; and P = 0.0002 and P < 0.0001, respectively, for strain FMR 8252). VRC reduced the fungal load in the spleen, kidneys and liver of infected mice for both strains tested. Survival of mice challenged with strain FMR 8252 treated with AMB did not differ from that of the control group ( P = 0.223), being worse than that of the mice treated with VRC ( P = 0.0002). AMB was not able to reduce the tissue burden in any organ with respect to the control group for both strains studied.