Epithelial apoptosis as a clinical marker in idiopathic interstitial pneumonia

• Published in: Respiratory medicine Vol. 104; no. 11; pp. 1722 - 1728
• Main Authors: Chung, Wou Young, Sun, Joo Sung, Park, Joo Hun, Lee, Hye Lim, Lee, Keu Sung, Kim, Young Sun, Sheen, Seung Soo, Park, Kyung Joo, Hwang, Sung Chul, Lee, Kyi Beom, Park, Kwang Joo
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.11.2010; Elsevier; Elsevier Limited
• Subjects: Aged; Apoptosis; Apoptosis - physiology; Biological and medical sciences; Biological markers; Biomarkers - blood; Cryptogenic organizing pneumonia; Disease; Enzyme-Linked Immunosorbent Assay; Epithelial cell; Epithelial Cells - pathology; Family medical history; Female; Forced Expiratory Volume - physiology; Humans; Idiopathic interstitial pneumonia; Idiopathic Interstitial Pneumonias - blood; Idiopathic Interstitial Pneumonias - pathology; Idiopathic Interstitial Pneumonias - physiopathology; Keratin-18 - blood; Lungs; Male; Medical sciences; Middle Aged; Pneumology; Pulmonary/Respiratory; Respiratory system : syndromes and miscellaneous diseases; Spirometry; Tomography; Tomography, X-Ray Computed; Epithelial cell; Idiopathic interstitial pneumonia; Biological markers; Cryptogenic organizing pneumonia; Apoptosis; Lung disease; Pneumonia; Respiratory disease; Idiopathic; Biological marker; Interstitial pneumonitis; Pneumology
• ISSN: 0954-6111; 1532-3064
• DOI: 10.1016/j.rmed.2010.05.013

Summary Backgrounds Epithelial cell apoptosis plays an important role in the pathogenesis of idiopathic interstitial pneumonia (IIP). Methods Serum levels of caspase-cleaved cytokeratin-18 (M30) were measured in 55 patients with IIP and 34 healthy controls using enzyme-linked immunosorbent assays. The IIP cases included usual interstitial pneumonia (UIP; n  = 30), nonspecific interstitial pneumonia (NSIP; n  = 15), and cryptogenic organizing pneumonia (COP; n  = 10). The radiological scoring was performed based on high-resolution computed tomography (HRCT) findings. Results Patients with IIP had higher serum M30 levels than did the control group (178.6 ± 91.5 vs. 113.7 ± 46.8 U/L, p  < 0.05). Among IIP patients, COP patients had higher serum M30 levels than did UIP or NSIP patients (264.9 ± 132.7, 139.2 ± 49.7, and 201.2 ± 81.1 U/L, respectively; COP vs. UIP, p  < 0.01). Serum M30 levels were negatively correlated with forced vital capacity (FVC; rs  = −0.31), percent-predicted FVC (FVC%; rs  = −0.38), and percent-predicted forced expiratory volume in 1 s (FEV1 %; rs  = −0.36). Serum M30 levels were correlated with radiological ground-glass opacity scores ( rs  = 0.61). Conclusion The epithelial apoptosis marker serum level was correlated with IIP clinical status and is a potential marker to assess IIP.