Effect of Tea (Camellia sinensis L.) on Lipid Peroxidation in Rat Liver and Kidney : a Comparison of Green and Black Tea Feeding

• Published in: Biological & pharmaceutical bulletin Vol. 18; no. 7; pp. 1006 - 1008
• Main Authors: SANO, Mitsuaki, OGUNI, Itaro, YOSHINO, Kyoji, KONOMOTO, Haruo, NAKAMURA, Yoshiyuki, TAKAHASHI, Yutaka, TOMITA, Isao, SHIMOI, Kayoko
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1995; Maruzen
• Subjects: Animals; antioxidant; Antioxidants - pharmacology; Biological and medical sciences; black tea; Body Weight - drug effects; Eating - drug effects; Electrocardiography - drug effects; epicatechin; General pharmacology; green tea; kidney; Kidney - drug effects; Kidney - metabolism; Lipid Peroxidation - drug effects; liver; Liver - drug effects; Liver - metabolism; Male; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - pharmacology; Rats; Rats, Wistar; Tea - chemistry; Thiobarbituric Acid Reactive Substances - metabolism; Vitamin E - metabolism; Rat; Liver; Lipids; Flavonoid; Polyphenol; Dicotyledones; Angiospermae; Inhibition; Beverage; Mechanism of action; Green tea; Food; Peroxidation; Pharmacognosy; Rodentia; Antioxidant; Biological activity; Vertebrata; Camellia sinensis; Mammalia; Animal; Plant origin; Spermatophyta; Comparative study; Theaceae
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.18.1006

The antioxidant effects in the liver and kidney obtained from rats fed diets containing 3% green or black tea leaf powder, which were prepared from the same lot tea leaves, were studied using the tissue slice-antioxidant evaluation method with two lipid peroxidation inducers. After 50 d on the diets, liver slices prepared from green and black tea-supplemented rats showed significant inhibitory effects against tert-butyl hydroperoxide-induced lipid peroxidation. These effects, however, were not proportional to the amounts of (-)-epicatechins and antioxidant vitamins in the tea leaves. In the kidney, the antioxidant effect was observed only in the green tea-fed group. A similar antioxidant effect on the kidney was observed after oral administration of a major tea polyphenol, (-)-epigallocatechin gallate (50 mg/kg body weight for. 7d). Liver slices from black tea-fed rats also inhibited bromotrichloromethane-induced lipid peroxidation. These results demonstrated that dietary green and black tea had antioxidant effects on tissue lipid peroxidation ex vivo.