Effects of Regular Exercise on Blood Pressure and Left Ventricular Hypertrophy in African-American Men with Severe Hypertension

• Published in: The New England journal of medicine Vol. 333; no. 22; pp. 1462 - 1467
• Main Authors: Kokkinos, Peter F, Narayan, Puneet, Colleran, John A, Pittaras, Andreas, Notargiacomo, Aldo, Reda, Domenic, Papademetriou, Vasilios
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 30.11.1995
• Subjects: Adult; African Americans; Aged; Antihypertensive Agents - therapeutic use; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Black or African American; Black People; Blood and lymphatic vessels; Blood Pressure; Cardiology. Vascular system; Cardiovascular disease; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Combined Modality Therapy; Drug therapy; Exercise; Humans; Hypertension; Hypertension - ethnology; Hypertension - physiopathology; Hypertension - therapy; Hypertrophy, Left Ventricular; Indapamide - therapeutic use; Male; Medical sciences; Middle Aged; Treatment Outcome; Verapamil - therapeutic use; United States; North America; America; Performance evaluation; Physical exercise; Human; Hypertension; Treatment; Negroid; Cardiovascular disease; Antihypertensive agent; Left ventricle; Hypertrophy
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM199511303332204

Chronic essential hypertension is a major risk factor for cardiovascular disease. 1 – 3 Morbidity and mortality from cardiovascular causes increase curvilinearly as blood pressure rises, with no evidence of a threshold of risk. 4 Antihypertensive therapy has reduced the incidence of congestive heart failure, renal failure, and stroke 4 – 6 but has failed to produce the expected reductions in coronary morbidity and mortality. 4 – 7 Various explanations have been proposed, including adverse effects of some antihypertensive agents on carbohydrate and lipid metabolism 8 , 9 and poor compliance with medication regimens. Even when drug therapy is effective, side effects and cost considerations lead to poor compliance . . .