Omeprazole inhibits IL-4 and IL-13 signaling signal transducer and activator of transcription 6 activation and reduces lung inflammation in murine asthma

• Published in: Journal of allergy and clinical immunology Vol. 124; no. 3; pp. 607 - 610.e1
• Main Authors: Cortes, Jose R., BSc, Rivas, Maria D., PhD, Molina-Infante, Javier, MD, Gonzalez-Nuñez, Maria A., MD, Perez-G, Moises, BSc, Masa, Juan F., MD, Sanchez, Juan F., MD, Zamorano, Jose, PhD
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.09.2009; Elsevier Limited
• Subjects: 2-Pyridinylmethylsulfinylbenzimidazoles - administration & dosage; Adenosine triphosphatase; Allergy and Immunology; Animals; Asthma; Asthma - drug therapy; Asthma - immunology; Cell Line, Tumor; Disease; Disease Models, Animal; Gastroesophageal reflux; Interleukin-13 - antagonists & inhibitors; Interleukin-4 - antagonists & inhibitors; Mice; Omeprazole - administration & dosage; Phosphorylation; Phosphorylation - drug effects; Pneumonia - drug therapy; Pneumonia - immunology; Proton Pump Inhibitors - administration & dosage; Signal Transduction - drug effects; Signal Transduction - immunology; STAT6 Transcription Factor - antagonists & inhibitors
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2009.06.023

In this case, omeprazole may convert to its active form in the acidic environment of asthmatic lung airways,8 facilitating its inhibitory activity. [...]the presence of inflammatory cells, including eosinophils, was significantly reduced in bronchoalveolar lavage fluid (Fig 2, D) and lung sections (see this article's Fig E1 in the Online Repository at www.jacionline.org) from omeprazole-treated animals.