Application of Genetically Modified and Cloned Pigs in Translational Research

Pigs are increasingly being recognized as good large-animal models for translational research, linking basic science to clinical applications in order to establish novel therapeutics. This article reviews the current status and future prospects of genetically modified and cloned pigs in translationa...

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Bibliographic Details
Published inJournal of Reproduction and Development Vol. 55; no. 3; pp. 225 - 230
Main Authors MATSUNARI, Hitomi, NAGASHIMA, Hiroshi
Format Journal Article
LanguageEnglish
Published Japan THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT 01.06.2009
Subjects
Animals
Animals, Genetically Modified
Biomedical Research - methods
Cloned pig
Cloning, Organism - methods
Cloning, Organism - statistics & numerical data
Disease Models, Animal
Gene knockout
Genes, Reporter - physiology
Models, Biological
Stem Cell Transplantation - methods
Swine - genetics
Transgenic pig
Translational research
Transplantation, Heterologous - methods
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Summary:Pigs are increasingly being recognized as good large-animal models for translational research, linking basic science to clinical applications in order to establish novel therapeutics. This article reviews the current status and future prospects of genetically modified and cloned pigs in translational studies. It also highlights pigs specially designed as disease models, for xenotransplantation or to carry cell marker genes. Finally, use of porcine somatic stem and progenitor cells in preclinical studies of cell transplantation therapy is also discussed.
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ISSN:0916-8818
1348-4400
DOI:10.1262/jrd.20164