Persistent perineal morbidity is common following abdominoperineal excision for rectal cancer

• Published in: International journal of colorectal disease Vol. 30; no. 11; pp. 1563 - 1570
• Main Authors: Asplund, Dan, Prytz, Mattias, Bock, David, Haglind, Eva, Angenete, Eva
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2015; Springer Nature B.V
• Subjects: Abdomen - surgery; Abdominoperineal excision; Aged; Cross-Sectional Studies; Female; Follow-Up Studies; Gastroenterology; Hepatology; Humans; Internal Medicine; Kirurgi; Male; Medicine; Medicine & Public Health; Original; Original Article; Perineal morbidity; Perineum - surgery; Postoperative Complications; Proctology; Quality of Life; Rectal cancer; Rectal Neoplasms - surgery; Risk Factors; Surgery; Surveys and Questionnaires; Time Factors; Wound Healing; Abdominoperineal excision; Rectal cancer; Perineal morbidity; Quality of life
• ISSN: 0179-1958; 1432-1262; 1432-1262
• DOI: 10.1007/s00384-015-2328-1

Purpose Short-term complications related to the perineal wound after abdominoperineal excision (APE) are a well-known problem. Perineal morbidity in the longer term is an almost unexplored area. The aim of this cross-sectional study was to investigate the prevalence of perineal symptoms 3 years after APE for rectal cancer, to identify potential risk factors and to explore the relationship between perineal morbidity and global quality of life. Method All patients who underwent APE in Sweden between 2007 and 2009 ( n  = 1373) were identified through the Swedish Colorectal Cancer Registry. Surviving patients were contacted 3 years after surgery and asked about participation. A total of 545 patients completed a detailed questionnaire. Clinical data was collected from the registry and surgical charts. Results Perineal symptoms occurred in 50 % of all patients 3 years after APE and more frequently in women (58 vs. 44 %; p  = 0.001). Delayed healing of the perineal wound (>4 weeks) occurred in 25 % of all patients and more frequently after extralevator APE (ELAPE) than after conventional APE (32 vs. 11 %, p  < 0.001). Delayed healing was associated with an increased risk of more severe perineal symptoms (relative risk (RR) 1.50, 95 % confidence interval (95 % CI) 1.09–2.05). Patients with more severe perineal symptoms ( n  = 129) had a significantly lower global quality of life as measured by EQ-5D visual analogue scale (VAS; median 75 vs. 83 points on the 100-point scale; p  < 0.001). Conclusion Persistent perineal symptoms are common after APE and may have an impact on patients’ quality of life. Delayed wound healing may be a risk factor for persistent symptoms. Further studies are needed to identify avoidable clinical factors for the development of persistent perineal morbidity. ClinicalTrials.gov Identifier NCT01296984