Proline-arginine rich (PR-39) cathelicidin: structure, expression and functional implication in intestinal health

Highlights • Cathelicidin proline-arginine-39 (PR-39) is key in porcine innate immuity. • PR-39 has immunomodulatory, wound healing, anti-apoptotic, and pro-angiogenic roles. • PR-39 may evolve as therapeutic alternative for infectious enterocolitis in pigs.

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Bibliographic Details
Published inComparative immunology, microbiology and infectious diseases Vol. 49; pp. 95 - 101
Main Authors Holani, Ravi, Shah, Chaitanya, Haji, Qahir, Inglis, G. Douglas, Uwiera, Richard R.E, Cobo, Eduardo R
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2016
Elsevier Science Ltd
Subjects
Adaptive Immunity
Adaptive systems
Allergy and Immunology
Amino Acid Sequence
Angiogenesis
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - immunology
Anti-Bacterial Agents - therapeutic use
Antiinfectives and antibacterials
Antimicrobial
Antimicrobial Cationic Peptides - chemistry
Antimicrobial Cationic Peptides - genetics
Antimicrobial Cationic Peptides - immunology
Antimicrobial Cationic Peptides - physiology
Antimicrobial Cationic Peptides - therapeutic use
Apoptosis
Arginine
Biological activity
Bone marrow
Cathelicidin
Enterocolitis
Enterocolitis - therapy
Enterocolitis - veterinary
Gram-positive bacteria
Hogs
Homeostasis
Immune system
Immunemodulator
Immunity, Innate
Immunomodulation
Infectious Disease
Innate immunity
Intestine
Intestines - immunology
Intestines - physiology
Leukocytes
Lymphoid tissue
Lysates
Microbial activity
Microorganisms
Neutrophil
Pig
Pork
PR-39
Proline
Proline-arginine-peptide
Spleen
Swine
Swine Diseases - therapy
Thymus
Wound healing
antimicrobial
proline-arginine-peptide
intestine
cathelicidin
infectious disease
PR-39
neutrophil
immunemodulator
pig
Cathelicidin
Proline-arginine-peptide
Antimicrobial
Infectious disease
Intestine
Immunemodulator
Neutrophil
Pig
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Summary:Highlights • Cathelicidin proline-arginine-39 (PR-39) is key in porcine innate immuity. • PR-39 has immunomodulatory, wound healing, anti-apoptotic, and pro-angiogenic roles. • PR-39 may evolve as therapeutic alternative for infectious enterocolitis in pigs.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0147-9571
1878-1667
DOI:10.1016/j.cimid.2016.10.004