SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination

• Published in: New England Journal of Medicine Vol. 386; no. 11; pp. 1088 - 1091
• Main Authors: Pajon, Rolando, Doria-Rose, Nicole A, Shen, Xiaoying, Schmidt, Stephen D, O’Dell, Sijy, McDanal, Charlene, Feng, Wenhong, Tong, Jin, Eaton, Amanda, Maglinao, Maha, Tang, Haili, Manning, Kelly E, Edara, Venkata-Viswanadh, Lai, Lilin, Ellis, Madison, Moore, Kathryn M, Floyd, Katharine, Foster, Stephanie L, Posavad, Christine M, Atmar, Robert L, Lyke, Kirsten E, Zhou, Tongqing, Wang, Lingshu, Zhang, Yi, Gaudinski, Martin R, Black, Walker P, Gordon, Ingelise, Guech, Mercy, Ledgerwood, Julie E, Misasi, John N, Widge, Alicia, Sullivan, Nancy J, Roberts, Paul C, Beigel, John H, Korber, Bette, Baden, Lindsey R, El Sahly, Hana, Chalkias, Spyros, Zhou, Honghong, Feng, Jing, Girard, Bethany, Das, Rituparna, Aunins, Anne, Edwards, Darin K, Suthar, Mehul S, Mascola, John R, Montefiori, David C
• Format: Journal Article Web Resource
• Language: English
• Published: United States Massachusetts Medical Society 17.03.2022
• Subjects: Coronavirus; Coronaviruses; Correspondence; COVID-19 vaccines; HIV; Human immunodeficiency virus; Immunization; Infectious Disease; Infectious diseases; Laboratories; Medical research; mRNA; Mutation; R&D; Research & development; Severe acute respiratory syndrome coronavirus 2; Vaccination; Vaccines; Viral Infections
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMc2119912

Neutralization of the omicron variant was assessed in serum samples obtained from persons who had received an mRNA-1273 booster. After the standard two-dose vaccine regimen, these titers were approximately 35 times lower than those against the D614G variant. However, boosters increased omicron neutralization by a factor of 20 — to levels that correlate with clinical resistance to infection.