Metastatic Cutaneous Squamous Cell Carcinoma Involving the Parotid Gland: Experience Outside of the Sun Belt

• Published in: OTO open : the official open access journal of the American Academy of Otolaryngology--Head and Neck Surgery Foundation Vol. 5; no. 1; pp. 2473974X20984720 - n/a
• Main Authors: Flukes, Stephanie, Long, Sallie, Lohia, Shivangi, Barker, Christopher A., Dunn, Lara A., Cracchiolo, Jennifer, Ganly, Ian, Patel, Snehal, Cohen, Marc A.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2021; John Wiley & Sons, Inc; Wiley
• Subjects: Cancer therapies; Clinical outcomes; cutaneous squamous cell carcinoma; Demographics; Exocrine glands; Lymphatic system; Medical prognosis; Metastasis; Original Research; outcomes; parotid; prognostic indicators; Skin cancer; Squamous cell carcinoma; United States > US; parotid; cutaneous squamous cell carcinoma; prognostic indicators; outcomes
• ISSN: 2473-974X; 2473-974X
• DOI: 10.1177/2473974X20984720

Objective To characterize a subset of patients with metastatic head and neck cutaneous squamous cell carcinoma in a tertiary North American center and describe oncologic outcomes following definitive treatment. Study Design Retrospective chart review. Setting National Cancer Institute–designated Comprehensive Cancer Center. Methods We conducted a retrospective chart review of patients with cutaneous squamous cell carcinoma with metastases to intraparotid lymph nodes who underwent parotidectomy between 1993 and 2020. Baseline patient and tumor characteristics were assessed. Regional control, disease-specific survival, and overall survival were estimated using Kaplan-Meier method. Multivariate analysis was used to determine the relationship between adverse pathological features and survival. Results A total of 122 patients were included. The median age was 76, 84.4% of patients were male, and 17.2% were immunosuppressed. Regional control, disease-specific survival, and overall survival were 68.5%, 70.7%, and 59.4% at 5 years, respectively. Perineural and lymphovascular invasion were predictive of worse disease-specific survival. Extracapsular spread was observed in 90.2% of patients and was not a significant predictor of outcome. Conclusions We found the demographics and oncologic outcomes of our cohort in the Northeast United States to be comparable with those previously reported in Australia and the Sun Belt of the United States. We noted a high rate of extracapsular spread but did not find it to be a significant predictor of recurrence or survival. Future efforts should address the impact of extracapsular spread on prognosis and adjuvant treatment decisions.