Circular RNA in gastric cancer

• Published in: Chinese medical journal Vol. 133; no. 15; pp. 1868 - 1877
• Main Authors: Li, Xue-Wei, Yang, Wen-Hui, Xu, Jun
• Format: Journal Article
• Language: English
• Published: China The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license 05.08.2020; Lippincott Williams & Wilkins Ovid Technologies; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, Shanxi 030001, China%Cancer Center of Shanxi Bethune Hospital, Taiyuan, Shanxi 030032, China%Department of Surgery, First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China; Wolters Kluwer Health; Wolters Kluwer
• Subjects: Apoptosis; Binding sites; Chemical bonds; Gastric cancer; Genes; Genomes; Humans; Kinases; Medical research; MicroRNAs; Prognosis; Proteins; Review; RNA, Circular; Stomach Neoplasms - diagnosis; Stomach Neoplasms - genetics; Circular RNA; Biomarker; Diagnosis; Gastric cancer
• ISSN: 0366-6999; 2542-5641; 2542-5641
• DOI: 10.1097/CM9.0000000000000908

Gastric cancer (GC) is a common malignancy and is the third leading cause of cancer-related death. At present, there is no simple and effective screening method for early-stage GC, and the treatment results and prognosis are poor. With the continuous improvement of molecular biology techniques, research on circular RNA (circRNA) has gradually expanded over time. Much data supports the role of circRNA in tumorigenesis. Moreover, due to its structural specificity and biological stability, circRNA is anticipated to be a potential biomarker for tumor diagnosis. Studies have confirmed that circRNA can participate in the proliferation, invasion, metastasis, and apoptosis of GC. These findings will lead to novel directions for the diagnosis and treatment of GC. This article reviews the structure and function of circRNA, summarizes the current studies on circRNA, and discusses the potential diagnostic value of circRNA in GC.