Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes

Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues of pulmonary arterial hypertension cases versus con...

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Published inPulmonary circulation Vol. 10; no. 4; pp. 1 - 5
Main Authors Romanoski, Casey E., Qi, Xinshuai, Sangam, Shreya, Vanderpool, Rebecca R., Stearman, Robert S., Conklin, Austin, Gonzalez-Garay, Manuel, Rischard, Franz, Ayon, Ramon J., Wang, Jian, Simonson, Tatum, Babicheva, Aleksandra, Shi, Yinan, Tang, Haiyang, Makino, Ayako, Kanthi, Yogendra, Geraci, Mark W., Garcia, Joe G.N., Yuan, Jason X.-J., Desai, Ankit A.
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.10.2020
John Wiley & Sons, Inc
Wiley
Subjects
PBMC
pulmonary arterial hypertension
Pulmonary hypertension
Research Letter
RNAseq
transcriptome profiling
transcriptome profiling
pulmonary arterial hypertension
PBMC
RNAseq
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Summary:Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues of pulmonary arterial hypertension cases versus controls, highlighting potentially novel candidate genes involved in pulmonary arterial hypertension development.
Bibliography:Contributed equally as first authors.
Contributed equally as senior authors.
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ISSN:2045-8940
2045-8932
2045-8940
DOI:10.1177/2045894020968531