Vigorous Osteoinductivity Observed in Crude Bone Morphogenetic Protein Stored for 25 Years after Extraction at Room Temperature

Bone morphogenetic protein (BMP) is the only cytokine that induces heterotopic new bone. BMP has been classified as a subfamily of the TGF superfamily. The most important and essential aspect for the clinical application of BMP is the replenishment and reinforcement of bone defects and fragile areas...

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Bibliographic Details
Published inJournal of Hard Tissue Biology Vol. 31; no. 4; pp. 253 - 256
Main Authors Miyazawa, Ken, Sekiya, Takeo, Kawaguchi, Misuzu, Kojima, Yuji, Tabuchi, Masako, Sato, Takuma, Kawai, Tatsushi, Goto, Shigemi
Format Journal Article
LanguageEnglish
Japanese
Published Tokyo THE SOCIETY FOR HARD TISSUE REGENERATIVE BIOLOGY 01.01.2022
The Society for Hard Tissue Regenerative Biology
Japan Science and Technology Agency
Subjects
BMP
Bone morphogenetic proteins
Cytokines
Fascia
Heterotopic new bone
Long term storage
Osteogenesis
Proteins
Replenishment
Room temperature
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Summary:Bone morphogenetic protein (BMP) is the only cytokine that induces heterotopic new bone. BMP has been classified as a subfamily of the TGF superfamily. The most important and essential aspect for the clinical application of BMP is the replenishment and reinforcement of bone defects and fragile areas with new bone. However, it is difficult to ascertain long term clinical results. In this study, we examined the osteogenic potential in mouse femoral fascia of crude BMP extracted from bovine bone that had been stored at room temperature for 25 years. The results showed vigorous osteogenesis. This study demonstrates the long-term stability of crude BMP.
ISSN:1341-7649
1880-828X
DOI:10.2485/jhtb.31.253