Alzheimer Mechanisms and Therapeutic Strategies

There are still no effective treatments to prevent, halt, or reverse Alzheimer's disease, but research advances over the past three decades could change this gloomy picture. Genetic studies demonstrate that the disease has multiple causes. Interdisciplinary approaches combining biochemistry, mo...

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Bibliographic Details
Published inCell Vol. 148; no. 6; pp. 1204 - 1222
Main Authors Huang, Yadong, Mucke, Lennart
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 16.03.2012
Subjects
Alzheimer disease
Alzheimer Disease - drug therapy
Alzheimer Disease - genetics
Alzheimer Disease - metabolism
Alzheimer Disease - physiopathology
Amyloid beta-Protein Precursor - metabolism
Animals
biomarkers
cell biology
chemistry
clinical trials
Cognition
drugs
gamma-Aminobutyric Acid - metabolism
genetically modified organisms
Humans
medicine
radiology
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Summary:There are still no effective treatments to prevent, halt, or reverse Alzheimer's disease, but research advances over the past three decades could change this gloomy picture. Genetic studies demonstrate that the disease has multiple causes. Interdisciplinary approaches combining biochemistry, molecular and cell biology, and transgenic modeling have revealed some of its molecular mechanisms. Progress in chemistry, radiology, and systems biology is beginning to provide useful biomarkers, and the emergence of personalized medicine is poised to transform pharmaceutical development and clinical trials. However, investigative and drug development efforts should be diversified to fully address the multifactoriality of the disease.
Bibliography:http://dx.doi.org/10.1016/j.cell.2012.02.040
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ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2012.02.040