Paradoxical worsening of pulmonary Mycobacterium abscessus

• Published in: Respiratory medicine Vol. 101; no. 4; pp. 868 - 870
• Main Authors: Yano, Shuichi, Kobayashi, Kanako, Kato, Kazuhiro, Tokuda, Yoshiyuki, Ikeda, Toshikazu, Takeyama, Hiroyasu
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.04.2007; Elsevier; Elsevier Limited
• Subjects: Aged; Anti-Bacterial Agents - therapeutic use; Biological and medical sciences; Cell Count; Consolidation; Deoxyribonucleic acid; DNA; Drug therapy; Female; Humans; Lung - pathology; Lung Diseases - diagnostic imaging; Lung Diseases - drug therapy; Lung Diseases - microbiology; Lymphocytes; Medical sciences; Mycobacterium abscessus; Mycobacterium Infections, Nontuberculous - diagnostic imaging; Mycobacterium Infections, Nontuberculous - drug therapy; Mycobacterium Infections, Nontuberculous - microbiology; Paradoxical worsening; Pneumology; Pulmonary/Respiratory; Tomography, X-Ray Computed - methods; Treatment Outcome; Tuberculosis; Mycobacterium abscessus; Paradoxical worsening; Mycobacteriales; Lung; Mycobacteriaceae; Bacteria; Actinomycetes; Aggravation; Pneumology
• ISSN: 0954-6111; 1532-3064
• DOI: 10.1016/j.rmed.2006.06.026

Summary Transient worsening of tuberculosis (TB) symptomatology and lesions in response to anti-TB therapy has previously been reported as paradoxical worsening. Recently, paradoxical worsening of TB following antiretroviral therapy in AIDS patients was reported. However, paradoxical worsening of nontuberculous mycobacterium, including Mycobacterium abscessus ( M. abscessus ), has not been reported previously. We reported the first case of paradoxical worsening of pulmonary M. abscessus.