Beyond Empiricism: Informing Vaccine Development through Innate Immunity Research

Although a great public heath success, vaccines provide suboptimal protection in some patient populations and are not available to protect against many infectious diseases. Insights from innate immunity research have led to a better understanding of how existing vaccines work and have informed vacci...

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Bibliographic Details
Published inCell Vol. 148; no. 6; pp. 1284 - 1292
Main Authors Levitz, Stuart M., Golenbock, Douglas T.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 16.03.2012
Subjects
adaptive immunity
adjuvants
Adjuvants, Immunologic - administration & dosage
Animals
antigens
Communicable Disease Control
Communicable Diseases - immunology
dendritic cells
Empiricism
Humans
immune response
Immunity, Innate
infectious diseases
innate immunity
patients
population
vaccine development
vaccines
Vaccines - immunology
Vaccines - therapeutic use
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Summary:Although a great public heath success, vaccines provide suboptimal protection in some patient populations and are not available to protect against many infectious diseases. Insights from innate immunity research have led to a better understanding of how existing vaccines work and have informed vaccine development. New adjuvants and delivery systems are being designed based upon their capacity to stimulate innate immune sensors and target antigens to dendritic cells, the cells responsible for initiating adaptive immune responses. Incorporating these adjuvants and delivery systems in vaccines can beneficially alter the quantitative and qualitative nature of the adaptive immune response, resulting in enhanced protection.
Bibliography:http://dx.doi.org/10.1016/j.cell.2012.02.012
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ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2012.02.012