Composition of receptor tyrosine kinase-mediated lipid micro-domains controlled by adaptor protein interaction

• Published in: Scientific reports Vol. 11; no. 1; p. 6160
• Main Authors: Rohwedder, Arndt, Knipp, Sabine, Roberts, Lee D., Ladbury, John E.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.03.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/337; 631/45; 631/535; 631/57; 631/57/2271; 631/80; Cell Membrane - metabolism; Corruption; Fibroblast growth factor receptor 2; GRB2 Adaptor Protein - metabolism; Grb2 protein; Growth factors; HEK293 Cells; Humanities and Social Sciences; Humans; Intracellular signalling; Ligands; Lipids; Membrane proteins; multidisciplinary; Protein Binding; Protein Domains; Protein interaction; Protein-tyrosine kinase receptors; Proteins; Receptor, Fibroblast Growth Factor, Type 2 - metabolism; Science; Science (multidisciplinary); Signal transduction

Receptor tyrosine kinases (RTKs) are highly regulated, single pass transmembrane proteins, fundamental to cellular function and survival. Aberrancies in regulation lead to corruption of signal transduction and a range of pathological outcomes. Although control mechanisms associated with the receptor...