Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review

• Published in: Foods Vol. 9; no. 3; p. 340
• Main Authors: Meng, Xiao, Zhou, Jing, Zhao, Cai-Ning, Gan, Ren-You, Li, Hua-Bin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.03.2020; MDPI
• Subjects: Alzheimer's disease; anti-obesity; anticancer; Anticancer properties; antidiabetes; antineoplastic activity; Antioxidants; Antitumor activity; Autophagy; Bioactive compounds; bioactivities; Cancer; Cardiovascular disease; Cardiovascular diseases; Clinical trials; Cytokines; Diabetes; Diabetes mellitus; dietary supplements; drugs; Enzymes; Epidemiology; Food science; Free radicals; Functional foods & nutraceuticals; Gene expression; glucose; Hazardous materials; Immunomodulation; Inflammation; Kinases; Lipids; liver; Liver cancer; Liver diseases; molecular mechanisms; Molecular modelling; Mortality; Movement disorders; Neurodegenerative diseases; Neuroprotection; obesity; Oxidative stress; Parkinson's disease; Proteins; Resveratrol; Review; Studies; Tumor necrosis factor-TNF; Viruses; molecular mechanisms; resveratrol; anticancer; antidiabetes; anti-obesity; bioactivities
• ISSN: 2304-8158; 2304-8158
• DOI: 10.3390/foods9030340

Resveratrol is a bioactive compound in many foods. Since its anticancer activity was reported in 1997, its health benefits have been intensively investigated. Resveratrol has antioxidant, anti-inflammatory, immunomodulatory, glucose and lipid regulatory, neuroprotective, and cardiovascular protective effects, therefore, can protect against diverse chronic diseases, such as cardiovascular diseases (CVDs), cancer, liver diseases, obesity, diabetes, Alzheimer’s disease, and Parkinson’s disease. This review summarizes the main findings of resveratrol-related health benefits in recent epidemiological surveys, experimental studies, and clinical trials, highlighting its related molecular mechanisms. Resveratrol, therefore, has been regarded as a potent candidate for the development of nutraceuticals and pharmaceuticals to prevent and treat certain chronic diseases.