Revised nomenclature of Clostridium difficile toxins and associated genes

• Published in: Journal of medical microbiology Vol. 54; no. 2; pp. 113 - 117
• Main Authors: Rupnik, Maja, Dupuy, Bruno, Fairweather, Neil F, Gerding, Dale N, Johnson, Stuart, Just, Ingo, Lyerly, David M, Popoff, Michel R, Rood, Julian I, Sonenshein, Abraham L, Thelestam, Monica, Wren, Brendan W, Wilkins, Tracy D, von Eichel-Streiber, Christoph
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Reading Soc General Microbiol 01.02.2005; Society for General Microbiology
• Subjects: Bacterial Proteins - genetics; Bacterial Toxins - genetics; Bacterial Toxins - isolation & purification; Biochemistry, Molecular Biology; Biological and medical sciences; Clostridium difficile; Clostridium difficile - genetics; Clostridium novyi; Clostridium sordellii; Enterotoxins - genetics; Fundamental and applied biological sciences. Psychology; Infectious diseases; Life Sciences; Medical sciences; Medicin och hälsovetenskap; Microbiology; Terminology as Topic; Toxin; Gene; Microbiology; Nomenclature; Clostridiaceae; Clostridium difficile; Clostridiales; Bacteria
• ISSN: 0022-2615; 1473-5644
• DOI: 10.1099/jmm.0.45810-0

1 University of Ljubljana, Department of Biology, Vecna pot 111, 1000 Ljubljana, Slovenia 2,8 Unité de Génétique Moléculaire Bactérienne 2 and Unité des Toxines Microbiennes 8 , Institut Pasteur, Paris, France 3 Centre for Molecular Microbiology and Infection, Imperial College, London, UK 4 Hines VA Hospital, Hospital/151 Fifth Avenue & Roosevelt Road, Hines, IL 60141, USA 5 Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA 6 Institute of Toxicology, Hannover Medical School, Hannover, Germany 7 TechLab Inc., Blacksburg, VA, USA 9 Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Victoria 3800, Australia 10 Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA 11 Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden 12 London School of Hygiene and Tropical Medicine, University of London, UK 13 Institute of Medical Microbiology and Hygiene, Johannes Gutenberg University of Mainz, D-55101 Mainz, Germany Correspondence Maja Rupnik maja.rupnik{at}bf.uni-lj.si Received July 3, 2004 Accepted August 6, 2004 Several different nomenclatures have been applied to the Clostridium difficile toxins and their associated genes. This paper summarizes the new nomenclature that has been agreed to by the research groups currently active in the field. The revised nomenclature includes C. difficile toxins and other related large clostridial toxins produced by Clostridium sordellii and Clostridium novyi , and corresponding toxin genes, as well as toxin production types of C. difficile strains. This paper was presented at the round-table discussion on Clostridium difficile nomenclature at the First International Clostridium difficile Symposium, Kranjska Gora, Slovenia, 5–7 May 2004. Abbreviation: LCT, large clostridial toxin.