Multi-modal and multi-scale clinical retinal imaging system with pupil and retinal tracking

We present a compact multi-modal and multi-scale retinal imaging instrument with an angiographic functional extension for clinical use. The system integrates scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT) and OCT angiography (OCTA) imaging modalities and provides multi-scale...

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Published inScientific reports Vol. 12; no. 1; pp. 9577 - 12
Main Authors Shirazi, Muhammad Faizan, Andilla, Jordi, Lefaudeux, Nicolas, Valdes, Claudia, Schwarzhans, Florian, Durand, Marine, Ntatsis, Konstantinos, De Jesus, Danilo Andrade, Sanchez Brea, Luisa, Gocho, Kiyoko, Gautier, Josselin, Eckmann-Hansen, Christina, Torm, Marie Elise Wistrup, Amini, Abdullah, Klein, Stefan, Van Walsum, Theo, Grieve, Kate, Paques, Michel, Larsen, Michael, Loza-Alvarez, Pablo, Levecq, Xavier, Chateau, Nicolas, Pircher, Michael
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 10.06.2022
Nature Publishing Group
Nature Portfolio
Subjects
639/624/1107/510
692/699/3161
692/700/1421
Angiography
Cellular Biology
Engineering
Humanities and Social Sciences
Humans
Life Sciences
Medical imaging
multidisciplinary
Ophthalmology
Ophthalmoscopy - methods
Optics
Optics and Photonics
Photoreceptors
Pupil
Retina
Retina - diagnostic imaging
Science
Science (multidisciplinary)
Subcellular Processes
Tomography
Tomography, Optical Coherence - methods
Visualization
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Abstract We present a compact multi-modal and multi-scale retinal imaging instrument with an angiographic functional extension for clinical use. The system integrates scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT) and OCT angiography (OCTA) imaging modalities and provides multi-scale fields of view. For high resolution, and high lateral resolution in particular, cellular imaging correction of aberrations by adaptive optics (AO) is employed. The entire instrument has a compact design and the scanning head is mounted on motorized translation stages that enable 3D self-alignment with respect to the subject’s eye by tracking the pupil position. Retinal tracking, based on the information provided by SLO, is incorporated in the instrument to compensate for retinal motion during OCT imaging. The imaging capabilities of the multi-modal and multi-scale instrument were tested by imaging healthy volunteers and patients.
AbstractList Abstract We present a compact multi-modal and multi-scale retinal imaging instrument with an angiographic functional extension for clinical use. The system integrates scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT) and OCT angiography (OCTA) imaging modalities and provides multi-scale fields of view. For high resolution, and high lateral resolution in particular, cellular imaging correction of aberrations by adaptive optics (AO) is employed. The entire instrument has a compact design and the scanning head is mounted on motorized translation stages that enable 3D self-alignment with respect to the subject’s eye by tracking the pupil position. Retinal tracking, based on the information provided by SLO, is incorporated in the instrument to compensate for retinal motion during OCT imaging. The imaging capabilities of the multi-modal and multi-scale instrument were tested by imaging healthy volunteers and patients.
We present a compact multi-modal and multi-scale retinal imaging instrument with an angiographic functional extension for clinical use. The system integrates scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT) and OCT angiography (OCTA) imaging modalities and provides multi-scale fields of view. For high resolution, and high lateral resolution in particular, cellular imaging correction of aberrations by adaptive optics (AO) is employed. The entire instrument has a compact design and the scanning head is mounted on motorized translation stages that enable 3D self-alignment with respect to the subject’s eye by tracking the pupil position. Retinal tracking, based on the information provided by SLO, is incorporated in the instrument to compensate for retinal motion during OCT imaging. The imaging capabilities of the multi-modal and multi-scale instrument were tested by imaging healthy volunteers and patients.
We present a compact multi-modal and multi-scale retinal imaging instrument with an angiographic functional extension for clinical use. The system integrates scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT) and OCT angiography (OCTA) imaging modalities and provides multi-scale fields of view. For high resolution, and high lateral resolution in particular, cellular imaging correction of aberrations by adaptive optics (AO) is employed. The entire instrument has a compact design and the scanning head is mounted on motorized translation stages that enable 3D self-alignment with respect to the subject's eye by tracking the pupil position. Retinal tracking, based on the information provided by SLO, is incorporated in the instrument to compensate for retinal motion during OCT imaging. The imaging capabilities of the multi-modal and multi-scale instrument were tested by imaging healthy volunteers and patients.We present a compact multi-modal and multi-scale retinal imaging instrument with an angiographic functional extension for clinical use. The system integrates scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT) and OCT angiography (OCTA) imaging modalities and provides multi-scale fields of view. For high resolution, and high lateral resolution in particular, cellular imaging correction of aberrations by adaptive optics (AO) is employed. The entire instrument has a compact design and the scanning head is mounted on motorized translation stages that enable 3D self-alignment with respect to the subject's eye by tracking the pupil position. Retinal tracking, based on the information provided by SLO, is incorporated in the instrument to compensate for retinal motion during OCT imaging. The imaging capabilities of the multi-modal and multi-scale instrument were tested by imaging healthy volunteers and patients.
ArticleNumber 9577
Author Andilla, Jordi
Larsen, Michael
Ntatsis, Konstantinos
Eckmann-Hansen, Christina
Grieve, Kate
Levecq, Xavier
Chateau, Nicolas
Durand, Marine
Gocho, Kiyoko
Klein, Stefan
De Jesus, Danilo Andrade
Sanchez Brea, Luisa
Amini, Abdullah
Paques, Michel
Gautier, Josselin
Lefaudeux, Nicolas
Loza-Alvarez, Pablo
Shirazi, Muhammad Faizan
Schwarzhans, Florian
Torm, Marie Elise Wistrup
Van Walsum, Theo
Pircher, Michael
Valdes, Claudia
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Snippet We present a compact multi-modal and multi-scale retinal imaging instrument with an angiographic functional extension for clinical use. The system integrates...
Abstract We present a compact multi-modal and multi-scale retinal imaging instrument with an angiographic functional extension for clinical use. The system...
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Angiography
Cellular Biology
Engineering
Humanities and Social Sciences
Humans
Life Sciences
Medical imaging
multidisciplinary
Ophthalmology
Ophthalmoscopy - methods
Optics
Optics and Photonics
Photoreceptors
Pupil
Retina
Retina - diagnostic imaging
Science
Science (multidisciplinary)
Subcellular Processes
Tomography
Tomography, Optical Coherence - methods
Visualization
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Title Multi-modal and multi-scale clinical retinal imaging system with pupil and retinal tracking
URI https://link.springer.com/article/10.1038/s41598-022-13631-1
https://www.ncbi.nlm.nih.gov/pubmed/35688890
https://www.proquest.com/docview/2675088169
https://www.proquest.com/docview/2675601140
https://inserm.hal.science/inserm-03726478
https://pubmed.ncbi.nlm.nih.gov/PMC9187716
https://doaj.org/article/12a6fc229709437998872823e2734a27
Volume 12
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