Multi-modal and multi-scale clinical retinal imaging system with pupil and retinal tracking

• Published in: Scientific reports Vol. 12; no. 1; pp. 9577 - 12
• Main Authors: Shirazi, Muhammad Faizan, Andilla, Jordi, Lefaudeux, Nicolas, Valdes, Claudia, Schwarzhans, Florian, Durand, Marine, Ntatsis, Konstantinos, De Jesus, Danilo Andrade, Sanchez Brea, Luisa, Gocho, Kiyoko, Gautier, Josselin, Eckmann-Hansen, Christina, Torm, Marie Elise Wistrup, Amini, Abdullah, Klein, Stefan, Van Walsum, Theo, Grieve, Kate, Paques, Michel, Larsen, Michael, Loza-Alvarez, Pablo, Levecq, Xavier, Chateau, Nicolas, Pircher, Michael
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.06.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 639/624/1107/510; 692/699/3161; 692/700/1421; Angiography; Cellular Biology; Engineering; Humanities and Social Sciences; Humans; Life Sciences; Medical imaging; multidisciplinary; Ophthalmology; Ophthalmoscopy - methods; Optics; Optics and Photonics; Photoreceptors; Pupil; Retina; Retina - diagnostic imaging; Science; Science (multidisciplinary); Subcellular Processes; Tomography; Tomography, Optical Coherence - methods; Visualization
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-13631-1

We present a compact multi-modal and multi-scale retinal imaging instrument with an angiographic functional extension for clinical use. The system integrates scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT) and OCT angiography (OCTA) imaging modalities and provides multi-scale fields of view. For high resolution, and high lateral resolution in particular, cellular imaging correction of aberrations by adaptive optics (AO) is employed. The entire instrument has a compact design and the scanning head is mounted on motorized translation stages that enable 3D self-alignment with respect to the subject’s eye by tracking the pupil position. Retinal tracking, based on the information provided by SLO, is incorporated in the instrument to compensate for retinal motion during OCT imaging. The imaging capabilities of the multi-modal and multi-scale instrument were tested by imaging healthy volunteers and patients.