Induced pluripotent stem cell technology for dissecting the cancer epigenome
Cancer arises through the accumulation of both genetic and epigenetic alterations. Although the causal role of genetic mutations on cancer development has been established in vivo, similar evidence for epigenetic alterations is limited. Moreover, mutual interactions between genetic mutations and epi...
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Published in | Cancer science Vol. 106; no. 10; pp. 1251 - 1256 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
John Wiley & Sons, Inc
01.10.2015
John Wiley & Sons, Ltd |
Subjects | |
Online Access | Get full text |
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Summary: | Cancer arises through the accumulation of both genetic and epigenetic alterations. Although the causal role of genetic mutations on cancer development has been established in vivo, similar evidence for epigenetic alterations is limited. Moreover, mutual interactions between genetic mutations and epigenetic alterations remain unclear. Cellular reprogramming technology can be used to actively modify the epigenome without affecting the underlying genomic sequences. Here we introduce recent studies that have utilized this property for cancer research. We propose that just as it has potential for regenerative medicine and disease modeling, cell reprogramming could also be a powerful tool for dissecting the role of the cancer epigenome in the development and maintenance of cancer cells.
Here we introduce recent studies that utilized iPS cell technology for cancer research. We propose that cell reprogramming could be a powerful tool for dissecting the role of the cancer epigenome on the development and maintenance of cancer cells. |
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Bibliography: | Funding Information The authors were supported in part by P‐DIRECT, a Grant‐in‐Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, by the Ministry of Health, Labor, and Welfare of Japan, by the SICORP, by the Takeda Science Foundation, by the Naito Foundation. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Funding InformationThe authors were supported in part by P-DIRECT, a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, by the Ministry of Health, Labor, and Welfare of Japan, by the SICORP, by the Takeda Science Foundation, by the Naito Foundation. |
ISSN: | 1347-9032 1349-7006 |
DOI: | 10.1111/cas.12758 |