Induced pluripotent stem cell technology for dissecting the cancer epigenome

Cancer arises through the accumulation of both genetic and epigenetic alterations. Although the causal role of genetic mutations on cancer development has been established in vivo, similar evidence for epigenetic alterations is limited. Moreover, mutual interactions between genetic mutations and epi...

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Bibliographic Details
Published inCancer science Vol. 106; no. 10; pp. 1251 - 1256
Main Authors Semi, Katsunori, Yamada, Yasuhiro
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.10.2015
John Wiley & Sons, Ltd
Subjects
Cancer
Cancer epigenetics
cancer model
Carcinogenesis - genetics
Cell Dedifferentiation
Cellular Reprogramming - genetics
Deoxyribonucleic acid
DNA
DNA methylation
Epigenesis, Genetic
Epigenetics
Epigenomics - methods
Genetic engineering
Genomes
Humans
Induced Pluripotent Stem Cells - metabolism
Inflammation
iPS cell
Leukemia
Mutation
Neoplasms - genetics
Oncogenes - genetics
Pediatrics
Pluripotency
Regenerative medicine
reprogramming
Review
Stem cells
Tumors
Japan
reprogramming
DNA methylation
cancer model
iPS cell
Cancer epigenetics
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Summary:Cancer arises through the accumulation of both genetic and epigenetic alterations. Although the causal role of genetic mutations on cancer development has been established in vivo, similar evidence for epigenetic alterations is limited. Moreover, mutual interactions between genetic mutations and epigenetic alterations remain unclear. Cellular reprogramming technology can be used to actively modify the epigenome without affecting the underlying genomic sequences. Here we introduce recent studies that have utilized this property for cancer research. We propose that just as it has potential for regenerative medicine and disease modeling, cell reprogramming could also be a powerful tool for dissecting the role of the cancer epigenome in the development and maintenance of cancer cells. Here we introduce recent studies that utilized iPS cell technology for cancer research. We propose that cell reprogramming could be a powerful tool for dissecting the role of the cancer epigenome on the development and maintenance of cancer cells.
Bibliography:Funding Information
The authors were supported in part by P‐DIRECT, a Grant‐in‐Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, by the Ministry of Health, Labor, and Welfare of Japan, by the SICORP, by the Takeda Science Foundation, by the Naito Foundation.
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Funding InformationThe authors were supported in part by P-DIRECT, a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, by the Ministry of Health, Labor, and Welfare of Japan, by the SICORP, by the Takeda Science Foundation, by the Naito Foundation.
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.12758