Emerging coronaviruses: Genome structure, replication, and pathogenesis

• Published in: Journal of Medical Virology Vol. 92; no. 4; pp. 418 - 423
• Main Authors: Chen, Yu, Liu, Qianyun, Guo, Deyin
• Format: Journal Article Web Resource
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2020; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Animals; Betacoronavirus - pathogenicity; Betacoronavirus - physiology; City centres; Communicable Diseases, Emerging - virology; Coronaviridae; coronavirus; Coronavirus - genetics; Coronavirus - pathogenicity; Coronavirus - physiology; Coronavirus Infections - veterinary; Coronavirus Infections - virology; Coronaviruses; COVID-19; epidemiology; Genome, Viral; Genomes; Host Specificity; Humans; Pathogenesis; Pneumonia, Viral - virology; Public health; Replication; respiratory tract; Review; Reviews; Risk; SARS-CoV-2; Viral Nonstructural Proteins - physiology; Viral Structural Proteins - physiology; Virology; virus classification; Virus Replication; Wildlife; zoonoses; epidemiology; pathogenesis; coronavirus; zoonoses; virus classification; respiratory tract
• ISSN: 0146-6615; 1096-9071
• DOI: 10.1002/jmv.25681

The recent emergence of a novel coronavirus (2019‐nCoV), which is causing an outbreak of unusual viral pneumonia in patients in Wuhan, a central city in China, is another warning of the risk of CoVs posed to public health. In this minireview, we provide a brief introduction of the general features of CoVs and describe diseases caused by different CoVs in humans and animals. This review will help understand the biology and potential risk of CoVs that exist in richness in wildlife such as bats. Highlights The general features of coronaviruses are introduced. The risk of emerging coronaviruses including the 2019‐nCoV is described. The genome structure and replication mechanism of coronaviruses are provided. The diseases caused by the major coronaviruses are listed.