Multifunctional PEGylated multiwalled carbon nanotubes for enhanced blood pool and tumor MR imaging

Long-circulating multifunctional Gd(III)-loaded multiwalled carbon nanotubes (MWCNTs) modified with polyethylene glycol are designed and synthesized. The formed MWCNTs are water-dispersible, stable, and have good cytocompatibility and antifouling property. With the low r 2 /r 1 relaxivity ratio and...

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Published inAdvanced healthcare materials Vol. 3; no. 10; p. 1568
Main Authors Wen, Shihui, Zhao, Qinghua, An, Xiao, Zhu, Jingyi, Hou, Wenxiu, Li, Kai, Huang, Yunpeng, Shen, Mingwu, Zhu, Wei, Shi, Xiangyang
Format Journal Article
LanguageEnglish
Published Germany 01.10.2014
Subjects
Animals
Gated Blood-Pool Imaging - methods
Magnetic Resonance Imaging - methods
Mice
Molecular Imaging - methods
Nanotubes, Carbon - chemistry
Neoplasms, Experimental - diagnosis
Neoplasms, Experimental - diagnostic imaging
Neoplasms, Experimental - pathology
Polyethylene Glycols
blood pool MR imaging
tumor MR imaging
multiwalled carbon nanotubes
PEGylation
polyethyleneimine
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Summary:Long-circulating multifunctional Gd(III)-loaded multiwalled carbon nanotubes (MWCNTs) modified with polyethylene glycol are designed and synthesized. The formed MWCNTs are water-dispersible, stable, and have good cytocompatibility and antifouling property. With the low r 2 /r 1 relaxivity ratio and relatively long blood circulation time, the multifunctional MWCNTs are able to be used as a platform for enhanced blood pool and tumor MR imaging.
ISSN:2192-2659
DOI:10.1002/adhm.201300631