The tired hippocampus: the molecular impact of sleep deprivation on hippocampal function

Highlights • Restoring hippocampal cAMP levels prevents sleep deprivation-induced memory deficits. • Blocking hippocampal PDE4A5 function prevents memory deficits caused by sleep loss. • Cofilin causes spine loss in CA1 neurons under conditions of sleep deprivation. • Attenuating cofilin activity pr...

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Bibliographic Details
Published inCurrent opinion in neurobiology Vol. 44; pp. 13 - 19
Main Authors Havekes, Robbert, Abel, Ted
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2017
Subjects
Hippocampus - physiopathology
Humans
Memory - physiology
Memory Disorders - physiopathology
Neurology
Neurons - pathology
Psychiatry
Signal Transduction - physiology
Sleep Deprivation - physiopathology
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Summary:Highlights • Restoring hippocampal cAMP levels prevents sleep deprivation-induced memory deficits. • Blocking hippocampal PDE4A5 function prevents memory deficits caused by sleep loss. • Cofilin causes spine loss in CA1 neurons under conditions of sleep deprivation. • Attenuating cofilin activity prevents sleep deprivation-induced memory impairments. • Restoring hippocampal mTORC1 signaling prevents sleep loss-induced memory deficits
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2017.02.005