Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise

• Published in: Behavioural brain research Vol. 198; no. 2; pp. 366 - 371
• Main Authors: Duman, Catharine H., Schlesinger, Lee, Terwilliger, Rosemarie, Russell, David S., Newton, Samuel S., Duman, Ronald S.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 17.03.2009; Elsevier
• Subjects: Animals; Antidepressant; Antidepressive Agents - pharmacology; Behavior; Behavior, Animal - drug effects; Behavioral psychophysiology; Biological and medical sciences; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - metabolism; Depression - drug therapy; Depression - psychology; Enzyme-Linked Immunosorbent Assay; Exercise; Exercise - psychology; Forced-swim test; Fundamental and applied biological sciences. Psychology; Humans; IGF-I; Immunoglobulin G - pharmacology; In Situ Hybridization; Injections, Subcutaneous; Insulin-Like Growth Factor I - administration & dosage; Insulin-Like Growth Factor I - antagonists & inhibitors; Insulin-Like Growth Factor I - genetics; Insulin-Like Growth Factor I - metabolism; Insulin-Like Growth Factor I - pharmacology; Insulin-Like Growth Factor I - physiology; Male; Medical sciences; Mice; Motor Activity - physiology; Mouse; Neuropharmacology; Novelty-induced hypophagia; Pharmacology. Drug treatments; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychopharmacology; Stress, Physiological - drug effects; Swimming - physiology; Time Factors; Antidepressant; IGF-I; Exercise; Mouse; Novelty-induced hypophagia; Behavior; Forced-swim test; Physical exercise; Psychotropic; Rodentia; Insulin like growth factor 1; Vertebrata; Mammalia; Animal; Antidepressant agent
• ISSN: 0166-4328; 1872-7549; 1872-7549
• DOI: 10.1016/j.bbr.2008.11.016

Growth factors in the brain are important to depression and it's treatment and we assessed the ability of peripherally administered insulin-like growth factor-I (IGF-I) to influence behavior related to depression. We found that mice that received chronic IGF-I treatment showed antidepressant-like behavior in forced-swim and novelty-induced hypophagia (NIH) tests and increased sucrose consumption after chronic mild unpredictable stress exposure. Additionally, peripheral anti-IGF-I administration blocked exercise-induced antidepressant effects in the forced-swim test (FST). These results support the functional relevance of neurotrophic mechanisms to depression and extend this idea to include neurotrophic factors in the periphery.