ANGPTL8 Gene Polymorphism rs2278426 Is Related to Carotid Intima–Media Thickness in T2DM

• Published in: Diabetes, metabolic syndrome and obesity Vol. 13; pp. 4519 - 4528
• Main Authors: Guo, Chang, Zhao, Li, Ding, Yi, Zhao, Zhicong, Wang, Chenxi, Li, Lian, Cai, Zhensheng, Li, Yanyan, Xia, Hong, Zhu, ZhuanZhuan, Yu, Fan, Dai, Meiqing, Deng, Xia, Yuan, Guoyue
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2020; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Adipose tissues; Analysis; angiopoietin‑like protein 8; Atherosclerosis; Cardiovascular disease; Cardiovascular diseases; Carotid arteries; carotid intima-media thickness; Cholesterol; Deoxyribonucleic acid; Dextrose; Diabetes; Disease prevention; Disease susceptibility; DNA; Enzymes; Ethylenediaminetetraacetic acid; Genes; Genetic aspects; Glucose; Insulin resistance; Lipids; Lipoproteins; Medical research; Medicine, Experimental; Metabolism; Mutation; Original Research; Physiological aspects; Polymorphism; Product information; rs2278426; Single nucleotide polymorphisms; Triglycerides; Type 2 diabetes; type 2 diabetes mellitus; Ultrasonic imaging; China; Beijing China; angiopoietin‑like protein 8; type 2 diabetes mellitus; polymorphism; carotid intima–media thickness; rs2278426
• ISSN: 1178-7007; 1178-7007
• DOI: 10.2147/DMSO.S274759

ANGPTL8 is a cytokine expressed and secreted by liver and adipose tissue, and is involved in glucose, lipid, and energy metabolism. Although studies have shown that ANGPTL8 is elevated in type 2 diabetes mellitus (T2DM) and cardiovascular disease, few have examined the association between single-nucleotide polymorphisms and the risk of macrovascular complications in T2DM patients. This study aimed to explore the relationship between rs2278426 and carotid intima-media thickening (cIMT) in T2DM. A total of 217 T2DM patients and 201 healthy control subjects with normal glucose tolerance were recruited in the study. T2DM patients were divided into two groups: T2DM patients without cIM thickening (cIMT <1 mm, 109 cases) and T2DM patients with cIM thickening (cIMT ≥1 mm, 108 cases). rs2278426 genotypes in all 418 subjects were determined and the risk of T2DM and T2DM with cIM thickening analyzed. CT+TT-genotype frequency in T2DM was higher than in controls with normal glucose tolerance, and the proportion of the CT+TT genotype in the group with cIMT was higher than in the group ( <0.05). In addition, T alleles were associated with waist:hip ratio, triglycerides, high density-lipoprotein cholesterol, plasma glucose at 2 hours' oral glucose tolerance, and homeostatic model assessment of insulin resistance ( <0.05). Generally, carriers of the T allele at rs2278426 are more likely to develop T2DM, and the risk of cIM thickening is significantly increased for T-allele carriers with T2DM, which indicates an increased risk of macroangiopathy.