Ape malaria transmission and potential for ape-to-human transfers in Africa

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 19; pp. 5329 - 5334
• Main Authors: Makanga, Boris, Yangari, Patrick, Rahola, Nil, Rougeron, Virginie, Elguero, Eric, Boundenga, Larson, Moukodoum, Nancy Diamella, Okouga, Alain Prince, Arnathau, Céline, Durand, Patrick, Willaume, Eric, Ayala, Diego, Fontenille, Didier, Ayala, Francisco J., Renaud, François, Ollomo, Benjamin, Prugnolle, Franck, Paupy, Christophe
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 10.05.2016
• Subjects: Animals; Anopheles; Anopheles - parasitology; Anopheles marshallii; Anopheles moucheti; Biodiversity; Biological Sciences; Disease transmission; Disease Vectors - classification; Ecology, environment; Entomology; Gabon; Genetics; Health; Hominidae - microbiology; Hominidae - parasitology; Humans; Life Sciences; Malaria; Malaria - parasitology; Monkeys & apes; Mosquitoes; Pan troglodytes; Plasmodium; Plasmodium - isolation & purification; Rainforest; Species Specificity; Zoonoses - microbiology; Zoonoses - parasitology; Gabon; Africa; African rainforest; Plasmodium; Anopheles; ape-to-human infection; Laverania
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.1603008113

Recent studies have highlighted the large diversity of malaria parasites infecting African great apes (subgenus Laverania) and their strong host specificity. Although the existence of genetic incompatibilities preventing the cross-species transfer may explain host specificity, the existence of vectors with a high preference for a determined host represents another possibility. To test this hypothesis, we undertook a 15-mo-long longitudinal entomological survey in two forest regions of Gabon, where wild apes live, at different heights under the canopy. More than 2,400 anopheline mosquitoes belonging to 18 species were collected. Among them, only three species of Anopheles were found infected with ape Plasmodium: Anopheles vinckei, Anopheles moucheti, and Anopheles marshallii. Their role in transmission was confirmed by the detection of the parasites in their salivary glands. Among these species, An. vinckei showed significantly the highest prevalence of infection and was shown to be able to transmit parasites of both chimpanzees and gorillas. Transmission was also shown to be conditioned by seasonal factors and by the heights of capture under the canopy. Moreover, human landing catches of sylvan Anopheles demonstrated the propensity of these three vector species to feed on humans when available. Our results suggest therefore that the strong host specificity observed in the Laveranias is not linked to a specific association between the vertebrate host and the vector species and highlight the potential role of these vectors as bridge between apes and humans.