Relationship between Human Papillomavirus Status and the Cervicovaginal Microbiome in Cervical Cancer

Uterine cervical cancer (CC) is a complex, multistep disease primarily linked to persistent infection with high-risk human papillomavirus (HR-HPV). However, it is widely acknowledged that HR-HPV infection alone cannot account for the formation and progression of CC. Emerging evidence suggests that t...

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Published inMicroorganisms (Basel) Vol. 11; no. 6; p. 1417
Main Authors Nguyen, Hong Duc Thi, Le, Tan Minh, Lee, Eunmi, Lee, Donghyeon, Choi, Yeseul, Cho, Junghwan, Park, Nora Jee-Young, Chong, Gun Oh, Seo, Incheol, Han, Hyung Soo
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 27.05.2023
MDPI
Subjects
bacteriotherapy
Cancer
Carcinogenesis
Carcinogens
Cervical cancer
cervical intraepithelial lesion
cervicovaginal microbiome
Cervix
Chemokines
Cytokines
Dysbacteriosis
Gene expression
Genomes
Health aspects
Health care
Human papillomavirus
Immune system
Infections
Kinases
Lymphocytes
Melanoma
Microbiomes
Microenvironments
Microorganisms
Papillomavirus infections
Pathogens
Physiological aspects
Probiotics
Proteins
Review
Risk factors
Sensors
Uterine cancer
Vagina
Viruses
Womens health
South Korea
cervicovaginal microbiome
bacteriotherapy
cervical intraepithelial lesion
cervical cancer
human papillomavirus
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Summary:Uterine cervical cancer (CC) is a complex, multistep disease primarily linked to persistent infection with high-risk human papillomavirus (HR-HPV). However, it is widely acknowledged that HR-HPV infection alone cannot account for the formation and progression of CC. Emerging evidence suggests that the cervicovaginal microbiome (CVM) also plays a significant role in HPV-related CC. Certain bacteria, such as spp., , , and , are currently being considered as potential microbiomarkers for HPV-positive CC. However, the composition of the CVM in CC is inconsistent; thus, further studies are needed. This review comprehensively discusses the complex interplay between HPV and the CVM in cervical carcinogenesis. It is postulated that the dynamic interaction between HPV and the CVM creates an imbalanced cervicovaginal microenvironment that triggers dysbiosis, enhances HPV persistence, and promotes cervical carcinogenesis. Moreover, this review aims to provide updated evidence on the potential role of bacteriotherapy, particularly probiotics, in the treatment of CC.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms11061417